Additional file 1 of A statistical measure for the skewness of X chromosome inactivation based on case-control design

Appendices and Supplementary tables and figures. Appendix A Derivation of the closed form of V without covariates; Appendix B Size and power results for testing γ=γ0; Tables S1-S2 Estimated CP (%), ML (%), MR (%), ML/(ML+MR) and DP (%) of the two-sided 95% CI when N=500, ρ=0.05, and λ2=1.5 or 2 for the LR, Fieller’s and delta methods, respectively; Tables S3-S4 Estimated CP (%), ML (%), MR (%), ML/(ML+MR) and DP (%) of the two-sided 95% CI when N=2000, ρ=0.05, and λ2=1.5 or 2 for the LR, Fieller’s and delta methods, respectively; Tables S5-S8 Estimated size (%) for testing H0: γ=γ0 with N=500 or 2000, and ρ=0 or 0.05 for the LR, Fieller’s and delta methods, respectively; Figures S1-S6 Power comparison of the LR, Fieller’s and delta methods against γ. The simulation is based on 10,000 replicates with N=500, ρ=0 or 0.05, and γ0=0, 1 or 2, respectively; Figures S7-S12 Power comparison of the LR, Fieller’s and delta methods against γ. The simulation is based on 10,000 replicates with N=2000, ρ=0 or 0.05, and γ0=0, 1 or 2, respectively. (PDF 117 kb