Biological evaluation of isoflavonoids from <i>Genista halacsyi</i> using estrogen-target cells: Activities of glucosides compared to aglycones - Fig 2

(A) Ribbon representation of ERα in complex with genistein (GEN, orange ribbons) and ortho-trifluoromethylphenylvinyl estradiol (EZT, light blue ribbons). The flexible region which accommodates the bulky group of EZT is inside the red circle. (B) Superposition of crystal structure of EZT with global minimum structure of 8 inside the binding pocket of ERα. (C) Superposition of global minimum structure of 12 with global minimum structure of 8 inside the binding pocket of ERα. (D) Superposition of crystal structure of genistein with global minimum structure of 8 inside the binding pocket of ERα. For clarity reasons Helix 1 has been removed from all figures. Hydrogen bonds are depicted with red dashed lines.