BKV infection of vascular endothelial cells triggers interferon β production and secretion of CXCL10.

Supernatants from mock or BKV-infected cultured RPTE, BVEC and LVEC cells were collected at the specified points after infection and evaluated for their levels of different cytokines. Cytokine levels for each cell type and condition tested are represented in the graphs. A. Production of IFNβ was increased in BKV-infected LVEC at 3 and 5 dpi. B. Production of CXCL10 (IP-10) was increased upon BKV-infection in both BVEC and LVEC endothelial cells, but not in RPTE cells. Error bars represent standard deviation for three measurements.