Percentage of trials with the estimated MTD inside the toxicity optimal interval and average percentage of patients receiving doses inside the optimal toxicity interval as a function of true distribution and dose scheme.

Nolan A. Wages
Ph. D
Nolan A. Wages
Ph. D. Partially
Ordered Phase
I Trials June
Nolan A. Wages
Ph. D. Partially
Ordered Phase
I Trials June

January 2012

• Fundamental assumption in Phase I designs is the monotonicity of the dose-toxicity curve • Dose-li...

Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs

Reid D. Landes (785704)
Shelly Y. Lensing (5884217)
Martin Hauer-Jensen (225286)

February 2019

The relative potency of one agent to another is commonly represented by the ratio of two quantal res...

Proportion of the study participants with respective understanding level of dosage regimen instructions (N = 400).

Eyayaw Ashete Belachew (13840796)
Ashenafi Kibret Sendekie (12646960)
Samuel Agegnew Wondm (14420056)
Emneteab Mesfin Ayele (14420059)
Adeladlew Kassie Netere (4621486)

January 2023

Proportion of the study participants with respective understanding level of dosage regimen instructi...

Percentage of trials with the estimated MTD inside the optimal MTD interval and average percentage of patients receiving doses inside the optimal MTD interval as a function of true sample size and dose scheme.

Márcio Augusto Diniz (6191303)
Mourad Tighiouart (243703)
André Rogatko (5658436)

January 2019

Percentage of trials with the estimated MTD inside the optimal MTD interval and average percentage o...

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on the optimal MTD interval (True MTD ± 0.15 × True MTD).

Márcio Augusto Diniz (6191303)
Mourad Tighiouart (243703)
André Rogatko (5658436)

January 2019

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on ...

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on the optimal toxicity interval (θ ± 0.10).

Márcio Augusto Diniz (6191303)
Mourad Tighiouart (243703)
André Rogatko (5658436)

January 2019

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on ...

Percentage volumes receiving at least X% of prescription dose (VX%) of organs at risk.

Kyeong-Hyeon Kim (5954705)
Jin-Beom Chung (4870483)
Tae Suk Suh (4002299)
Sang-Won Kang (2372773)
Seong-Hee Kang (5954708)
Keun-Yong Eom (728442)
Changhoon Song (728439)
In-Ah Kim (5954711)
Jae-Sung Kim (605888)

November 2018

Percentage volumes receiving at least X% of prescription dose (VX%) of organs at risk.</p

Dose selection percentage and average number patients allocated to each dose under proposed design.

Haitao Pan (454047)
Ping Huang (30439)
Zuoren Wang (192732)
Ling Wang (56577)
Chanjuan Li (139028)
Jielai Xia (139031)

September 2013

Note: In each scenario, the first row of number in parentheses corresponds to the dose selection ...

Comparison of all normalized tallied indices.

Ivaylo B. Mihaylov (4781973)
Eric A. Mellon (3362057)
Raphael Yechieli (4781976)
Lorraine Portelance (4781979)

January 2018

Normalization is performed with respect to the doses derived from the treatment plans and plotted...

Robust optimal interval design for high-dimensional dose finding in multi-agent combination trials

Lin, R
Yin, G

January 2016

In the era of precision medicine, combination therapy is playing a more and more important role in d...

Percentile plot of the percent of ordered doses that were administered for each patient on the patient floor with the highest overall administration rate (black) and the patient floor with the lowest overall administration rate (orange).

Kenneth M. Shermock (422021)
Brandyn D. Lau (422022)
Elliott R. Haut (422023)
Deborah B. Hobson (422024)
Valerie S. Ganetsky (422025)
Peggy S. Kraus (422026)
Leigh E. Efird (422027)
Christoph U. Lehmann (422028)
Brian L. Pinto (422029)
Patricia A. Ross (422030)
Michael B. Streiff (422031)

June 2013

Percentile plot of the percent of ordered doses that were administered for each patient on the pa...

Generalized Likelihood Ratios for Designing Dose Optimization Studies of Targeted Therapies

Zhiwei Zhang (12077)
Yan Li (23143)

October 2023

Dose optimization studies of new therapeutic agents aim to identify one or more promising doses for ...

Percentages of trials in which targets were correctly identified.

Rolf Verleger (263580)
Marie Dittmer (381439)
Kamila Śmigasiewicz (381440)

February 2013

Values are mean percentages across participants (SD). T1 percentages were computed as numbers of ...

Percentage of the lesion volume covered by the dose prescription and the volume of normal tissue that received a dose of 12 Gy or higher for corrected and uncorrected SFD measurements.

Olivia A. García-Garduño (5220386)
Manuel A. Rodríguez-Ávila (5220389)
José M. Lárraga-Gutiérrez (5220383)

May 2018

Percentage of the lesion volume covered by the dose prescription and the volume of normal tissue ...

Phase I clinical trial designs: range and trend of expected toxicity level in standard A+B designs and an extended isotonic design treating toxicity as a quasi-continuous variable

Chen, Zhengjia

February 2009

UnrestrictedThe current designs of Phase I trials are comprehensively reviewed and classified by alg...

Partial Ordering of Doses

Nolan A. Wages
Ph. D
Nolan A. Wages
Ph. D. Partially
Ordered Phase
I Trials June
Nolan A. Wages
Ph. D. Partially
Ordered Phase
I Trials June

January 2012

• Fundamental assumption in Phase I designs is the monotonicity of the dose-toxicity curve • Dose-li...

Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs

Reid D. Landes (785704)
Shelly Y. Lensing (5884217)
Martin Hauer-Jensen (225286)

February 2019

The relative potency of one agent to another is commonly represented by the ratio of two quantal res...

Proportion of the study participants with respective understanding level of dosage regimen instructions (N = 400).

Eyayaw Ashete Belachew (13840796)
Ashenafi Kibret Sendekie (12646960)
Samuel Agegnew Wondm (14420056)
Emneteab Mesfin Ayele (14420059)
Adeladlew Kassie Netere (4621486)

January 2023

Proportion of the study participants with respective understanding level of dosage regimen instructi...

Percentage of trials with the estimated MTD inside the optimal MTD interval and average percentage of patients receiving doses inside the optimal MTD interval as a function of true sample size and dose scheme.

Márcio Augusto Diniz (6191303)
Mourad Tighiouart (243703)
André Rogatko (5658436)

January 2019

Percentage of trials with the estimated MTD inside the optimal MTD interval and average percentage o...

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on the optimal MTD interval (True MTD ± 0.15 × True MTD).

Márcio Augusto Diniz (6191303)
Mourad Tighiouart (243703)
André Rogatko (5658436)

January 2019

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on ...

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on the optimal toxicity interval (θ ± 0.10).

Márcio Augusto Diniz (6191303)
Mourad Tighiouart (243703)
André Rogatko (5658436)

January 2019

Percentage (Number) of doses relative to each discrete dose scheme which are optimal doses based on ...

Percentage volumes receiving at least X% of prescription dose (VX%) of organs at risk.

Kyeong-Hyeon Kim (5954705)
Jin-Beom Chung (4870483)
Tae Suk Suh (4002299)
Sang-Won Kang (2372773)
Seong-Hee Kang (5954708)
Keun-Yong Eom (728442)
Changhoon Song (728439)
In-Ah Kim (5954711)
Jae-Sung Kim (605888)

November 2018

Percentage volumes receiving at least X% of prescription dose (VX%) of organs at risk.</p

Dose selection percentage and average number patients allocated to each dose under proposed design.

Haitao Pan (454047)
Ping Huang (30439)
Zuoren Wang (192732)
Ling Wang (56577)
Chanjuan Li (139028)
Jielai Xia (139031)

September 2013

Note: In each scenario, the first row of number in parentheses corresponds to the dose selection ...

Comparison of all normalized tallied indices.

Ivaylo B. Mihaylov (4781973)
Eric A. Mellon (3362057)
Raphael Yechieli (4781976)
Lorraine Portelance (4781979)

January 2018

Normalization is performed with respect to the doses derived from the treatment plans and plotted...

Robust optimal interval design for high-dimensional dose finding in multi-agent combination trials

Lin, R
Yin, G

January 2016

In the era of precision medicine, combination therapy is playing a more and more important role in d...

Percentile plot of the percent of ordered doses that were administered for each patient on the patient floor with the highest overall administration rate (black) and the patient floor with the lowest overall administration rate (orange).

Kenneth M. Shermock (422021)
Brandyn D. Lau (422022)
Elliott R. Haut (422023)
Deborah B. Hobson (422024)
Valerie S. Ganetsky (422025)
Peggy S. Kraus (422026)
Leigh E. Efird (422027)
Christoph U. Lehmann (422028)
Brian L. Pinto (422029)
Patricia A. Ross (422030)
Michael B. Streiff (422031)

June 2013

Percentile plot of the percent of ordered doses that were administered for each patient on the pa...

Generalized Likelihood Ratios for Designing Dose Optimization Studies of Targeted Therapies

Zhiwei Zhang (12077)
Yan Li (23143)

October 2023

Dose optimization studies of new therapeutic agents aim to identify one or more promising doses for ...

Percentages of trials in which targets were correctly identified.

Rolf Verleger (263580)
Marie Dittmer (381439)
Kamila Śmigasiewicz (381440)

February 2013

Values are mean percentages across participants (SD). T1 percentages were computed as numbers of ...

Percentage of the lesion volume covered by the dose prescription and the volume of normal tissue that received a dose of 12 Gy or higher for corrected and uncorrected SFD measurements.

Olivia A. García-Garduño (5220386)
Manuel A. Rodríguez-Ávila (5220389)
José M. Lárraga-Gutiérrez (5220383)

May 2018

Percentage of the lesion volume covered by the dose prescription and the volume of normal tissue ...

Phase I clinical trial designs: range and trend of expected toxicity level in standard A+B designs and an extended isotonic design treating toxicity as a quasi-continuous variable

Chen, Zhengjia

February 2009

UnrestrictedThe current designs of Phase I trials are comprehensively reviewed and classified by alg...

Partial Ordering of Doses

Nolan A. Wages
Ph. D
Nolan A. Wages
Ph. D. Partially
Ordered Phase
I Trials June
Nolan A. Wages
Ph. D. Partially
Ordered Phase
I Trials June

January 2012

• Fundamental assumption in Phase I designs is the monotonicity of the dose-toxicity curve • Dose-li...

Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs

Reid D. Landes (785704)
Shelly Y. Lensing (5884217)
Martin Hauer-Jensen (225286)

February 2019

The relative potency of one agent to another is commonly represented by the ratio of two quantal res...

Proportion of the study participants with respective understanding level of dosage regimen instructions (N = 400).

Eyayaw Ashete Belachew (13840796)
Ashenafi Kibret Sendekie (12646960)
Samuel Agegnew Wondm (14420056)
Emneteab Mesfin Ayele (14420059)
Adeladlew Kassie Netere (4621486)

January 2023

Proportion of the study participants with respective understanding level of dosage regimen instructi...

Percentage of trials with the estimated MTD inside the toxicity optimal interval and average percentage of patients receiving doses inside the optimal toxicity interval as a function of true distribution and dose scheme.

Abstract

Extracted data

Percentage of trials with the estimated MTD inside the toxicity optimal interval and average percentage of patients receiving doses inside the optimal toxicity interval as a function of true distribution and dose scheme.

Abstract

Extracted data

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