Additional file 8: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

Publication date

January 2019

DOI

10.6084/m9.figshare.7580801.v1

Abstract

Figure S8. qRT-PCR analysis of VEGF, PDGF-BB, IGF-1, Ang-1, and bFGF in hypoxic MSCs (n = 3–4). **P < 0.01. VEGF vascular endothelial growth factor, PDGF-BB platelet-derived growth factor-BB, IGF-1 insulin-like growth factor 1, Ang-1 angiopoietin-1, bFGF fibroblast growth factor-basic, ns not significant. (PDF 133 kb

Extracted data

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Additional file 8: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

Open link

Publication date

January 2019

DOI

10.6084/m9.figshare.7580801.v1

Abstract

Extracted data

Byeong-Wook Song (3546602)
Il-Kwon Kim (145763)
Seahyoung Lee (3546614)
Eunhyun Choi (2012788)
Onju Ham (3546608)
Se-Yeon Lee (3546590)
Chang Lee (3546605)
Jun-Hee Park (3546593)
Jiyun Lee (1985284)
Hyang-Hee Seo (3546617)
Woochul Chang (3546611)
Cheesoon Yoon (3546599)
Ki-Chul Hwang (3546596)

September 2015

EC marker expression in iMDFECs. MSCs treated with SB for 16 days to induce EC differentiation. (A) ...

Additional file 1: of Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

Victor Martinez (2539555)
Imelda Ontoria-Oviedo (798472)
Carolina Ricardo (4480828)
Sian Harding (4480822)
Rosa Sacedon (4480825)
Alberto Varas (760278)
Agustin Zapata (370545)
Pilar Sepulveda (3633409)
Angeles Vicente (760277)

September 2017

Detailed methods: lentiviral production and transduction, metabolic assays, and list of reagents for...

Additional file 1: of IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia

Nianhuan Zhao (6648800)
Zhiwei Yue (6447800)
Jian Cui (182110)
Yong Yao (530522)
Xianghe Song (6648809)
Bangping Cui (6648812)
Xin Qi (177590)
Zhibo Han (5697452)
Zhong-Chao Han (529691)
Zhikun Guo (798942)
Zuo-Xiang He (417104)
Zongjin Li (38031)

April 2019

Table S1. RT-PCR primer sequences (human). Table S2. RT-PCR primer sequences (mouse). Figure S1. Cha...

Additional file 6: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S6. qRT-PCR analysis of M1 (iNOS, CD80) and M2 markers (Argnase-1, CD206) in peri-infarct myo...

Additional file 4: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S4. qRT-PCR analysis of CTGF in peri-infarct myocardium on post-therapy 7 days (n = 4). ***P ...

Additional file 1: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S1. Murine heart tissue around the injection site was collected 1 day after myocardial delive...

Additional file 5: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S5. Serum TNF-α (a) and IL-1β (b) on post-therapy 7 days was determined by ELISA (n = 4). TNF...

Additional file 7: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S7. Representative images (a) and quantification (b) of CD31 staining within the infarct bord...

Additional file 3: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S3. Changing tendency of post-MI EF (a) and FS (b) on indicated time points were determined (...

Additional file 2: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S2. Echocardiographic parameters regarding wall thickness and LV mass of post-MI hearts. IVS;...

Additional file 7: Figure S5. of Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model

Guadalupe Gómez-Mauricio (3413954)
Isabel Moscoso (3413960)
María-Fernanda Martín-Cancho (3413966)
Verónica Crisóstomo (713860)
Cristina Prat-Vidal (119545)
Claudia Báez-Díaz (3413963)
Francisco Sánchez-Margallo (3413957)
Antonio Bernad (13354)

July 2016

(A) Immunohistocytochemistry analysis in control animals (transplanted but not infarcted). Animal tr...

Additional file 9: of Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Meikuang Lim (5212004)
Weiqiang Wang (400116)
Lu Liang (155494)
Zhi-bo Han (5212007)
Zongjin Li (38031)
Jie Geng (193242)
Meng Zhao (54299)
Honghong Jia (5212016)
Jie Feng (8115)
Zhe Wei (260715)
Baoquan Song (3549287)
Jiemin Zhang (5212019)
Jun Li (6494)
Tianwen Liu (5212013)
Fan Wang (135182)
Ting Li (117885)
Jianming Li (228454)
Yihu Fang (5212010)
Jianhua Gao (332740)
Zhongchao Han (4320892)

May 2018

Figure S8. In vivo trafficking of intravenous injection of allogeneic UC-MSCs-eGFP 7 days after AMI ...

Additional file 10: of miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4

Jun Dong (43792)
Zhenhui Zhang (847340)
Hongshen Huang (5319845)
Pei Mo (5319836)
Chuanfan Cheng (5319842)
Jianwei Liu (163716)
Weizhao Huang (5319848)
Chaowei Tian (5319839)
Chongyu Zhang (3192726)
Jiao Li (261359)

May 2018

Figure S9. Expression of VEGF and SDF mRNA in mouse hearts after MI and hBM-MSCs. (A) Expression of ...

Additional file 2: of Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia

Ahmed Saad (3476342)
Xiang-Yang Zhu (430176)
Sandra Herrmann (3476348)
LaTonya Hickson (3476360)
Hui Tang (226667)
Allan Dietz (3476345)
Andre van Wijnen (3476351)
Lilach Lerman (3476354)
Stephen Textor (3476357)

September 2016

Hypoxia increased the expression of more than 460 genes. This set mRNAs encode regulators of metabol...

Byeong-Wook Song (3546602)
Il-Kwon Kim (145763)
Seahyoung Lee (3546614)
Eunhyun Choi (2012788)
Onju Ham (3546608)
Se-Yeon Lee (3546590)
Chang Lee (3546605)
Jun-Hee Park (3546593)
Jiyun Lee (1985284)
Hyang-Hee Seo (3546617)
Woochul Chang (3546611)
Cheesoon Yoon (3546599)
Ki-Chul Hwang (3546596)

September 2015

EC marker expression in iMDFECs. MSCs treated with SB for 16 days to induce EC differentiation. (A) ...

Additional file 1: of Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

Victor Martinez (2539555)
Imelda Ontoria-Oviedo (798472)
Carolina Ricardo (4480828)
Sian Harding (4480822)
Rosa Sacedon (4480825)
Alberto Varas (760278)
Agustin Zapata (370545)
Pilar Sepulveda (3633409)
Angeles Vicente (760277)

September 2017

Detailed methods: lentiviral production and transduction, metabolic assays, and list of reagents for...

Additional file 1: of IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia

Nianhuan Zhao (6648800)
Zhiwei Yue (6447800)
Jian Cui (182110)
Yong Yao (530522)
Xianghe Song (6648809)
Bangping Cui (6648812)
Xin Qi (177590)
Zhibo Han (5697452)
Zhong-Chao Han (529691)
Zhikun Guo (798942)
Zuo-Xiang He (417104)
Zongjin Li (38031)

April 2019

Table S1. RT-PCR primer sequences (human). Table S2. RT-PCR primer sequences (mouse). Figure S1. Cha...

Additional file 6: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S6. qRT-PCR analysis of M1 (iNOS, CD80) and M2 markers (Argnase-1, CD206) in peri-infarct myo...

Additional file 4: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S4. qRT-PCR analysis of CTGF in peri-infarct myocardium on post-therapy 7 days (n = 4). ***P ...

Additional file 1: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S1. Murine heart tissue around the injection site was collected 1 day after myocardial delive...

Additional file 5: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S5. Serum TNF-α (a) and IL-1β (b) on post-therapy 7 days was determined by ELISA (n = 4). TNF...

Additional file 7: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S7. Representative images (a) and quantification (b) of CD31 staining within the infarct bord...

Additional file 3: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S3. Changing tendency of post-MI EF (a) and FS (b) on indicated time points were determined (...

Additional file 2: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Han Shen (597537)
Guanghao Cui (3590414)
Yanqiong Li (584353)
Wenxue Ye (438612)
Yimin Sun (184945)
Zihan Zhang (3117441)
Jingjing Li (7654)
Guiying Xu (1829254)
Xiansheng Zeng (474807)
Yanxia Zhang (483434)
Wencheng Zhang (1530301)
Zan Huang (440996)
Weiqian Chen (844929)
Zhenya Shen (3419927)

January 2019

Figure S2. Echocardiographic parameters regarding wall thickness and LV mass of post-MI hearts. IVS;...

Guadalupe Gómez-Mauricio (3413954)
Isabel Moscoso (3413960)
María-Fernanda Martín-Cancho (3413966)
Verónica Crisóstomo (713860)
Cristina Prat-Vidal (119545)
Claudia Báez-Díaz (3413963)
Francisco Sánchez-Margallo (3413957)
Antonio Bernad (13354)

July 2016

(A) Immunohistocytochemistry analysis in control animals (transplanted but not infarcted). Animal tr...

Meikuang Lim (5212004)
Weiqiang Wang (400116)
Lu Liang (155494)
Zhi-bo Han (5212007)
Zongjin Li (38031)
Jie Geng (193242)
Meng Zhao (54299)
Honghong Jia (5212016)
Jie Feng (8115)
Zhe Wei (260715)
Baoquan Song (3549287)
Jiemin Zhang (5212019)
Jun Li (6494)
Tianwen Liu (5212013)
Fan Wang (135182)
Ting Li (117885)
Jianming Li (228454)
Yihu Fang (5212010)
Jianhua Gao (332740)
Zhongchao Han (4320892)

May 2018

Figure S8. In vivo trafficking of intravenous injection of allogeneic UC-MSCs-eGFP 7 days after AMI ...

Additional file 10: of miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4

Jun Dong (43792)
Zhenhui Zhang (847340)
Hongshen Huang (5319845)
Pei Mo (5319836)
Chuanfan Cheng (5319842)
Jianwei Liu (163716)
Weizhao Huang (5319848)
Chaowei Tian (5319839)
Chongyu Zhang (3192726)
Jiao Li (261359)

May 2018

Figure S9. Expression of VEGF and SDF mRNA in mouse hearts after MI and hBM-MSCs. (A) Expression of ...

Additional file 2: of Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia

Ahmed Saad (3476342)
Xiang-Yang Zhu (430176)
Sandra Herrmann (3476348)
LaTonya Hickson (3476360)
Hui Tang (226667)
Allan Dietz (3476345)
Andre van Wijnen (3476351)
Lilach Lerman (3476354)
Stephen Textor (3476357)

September 2016

Hypoxia increased the expression of more than 460 genes. This set mRNAs encode regulators of metabol...

Byeong-Wook Song (3546602)
Il-Kwon Kim (145763)
Seahyoung Lee (3546614)
Eunhyun Choi (2012788)
Onju Ham (3546608)
Se-Yeon Lee (3546590)
Chang Lee (3546605)
Jun-Hee Park (3546593)
Jiyun Lee (1985284)
Hyang-Hee Seo (3546617)
Woochul Chang (3546611)
Cheesoon Yoon (3546599)
Ki-Chul Hwang (3546596)

September 2015

EC marker expression in iMDFECs. MSCs treated with SB for 16 days to induce EC differentiation. (A) ...

Additional file 1: of Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

Victor Martinez (2539555)
Imelda Ontoria-Oviedo (798472)
Carolina Ricardo (4480828)
Sian Harding (4480822)
Rosa Sacedon (4480825)
Alberto Varas (760278)
Agustin Zapata (370545)
Pilar Sepulveda (3633409)
Angeles Vicente (760277)

September 2017

Detailed methods: lentiviral production and transduction, metabolic assays, and list of reagents for...

Additional file 1: of IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia

Nianhuan Zhao (6648800)
Zhiwei Yue (6447800)
Jian Cui (182110)
Yong Yao (530522)
Xianghe Song (6648809)
Bangping Cui (6648812)
Xin Qi (177590)
Zhibo Han (5697452)
Zhong-Chao Han (529691)
Zhikun Guo (798942)
Zuo-Xiang He (417104)
Zongjin Li (38031)

April 2019

Table S1. RT-PCR primer sequences (human). Table S2. RT-PCR primer sequences (mouse). Figure S1. Cha...

Additional file 8: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Abstract

Extracted data

Additional file 8: of Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

Abstract

Extracted data

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