(A) Supernatants from CD8+ T cell cultures, before (0) and 2–3 days after in vitro activation with anti-CD3/28 were recovered and the level of inflammatory cytokines was measured using a cytometric bead array. Data pooled from 3 independent experiments. Bars represent the mean + SEM. (B-C) TCR transgenic OT-I CD8+ T cells and B6 CD8+ T cells were mixed 1:1 and co-cultured in the presence of SIINFEKL peptide for 3 days. After co-culture, OT-I and B6 cells were sort purified and levels of IFITM3 expression were determined by western blot. (B) Schematic of the experimental procedure. (C) Western blot depicting levels of IFITM3 expression. Data are representative of 3 experiments. Actin was included as a loading control throughout. (D) CFSE-lab...
<p>Cells were collected from spleens of CD11c-<i>Ifnar1</i><sup>-/-</sup> mice and littermate contro...
<p>Cells were collected from spleens, MLNs, or Peyer’s patches of CD11c-<i>Ifnar1</i><sup>-/-</sup> ...
In response to acute virus infections, CD8(+) T cells differentiate to form a large population of sh...
(A) Western blot analysis of IFITM3 expression by CD8+ T cells before (0) and after in vitro activat...
<p>(<b>a–d</b>) CD8+ T cell proliferation under various stimuli. Cultures were incubated for 48 hour...
<p>Ifitm3 protein expression can also be induced by gp130-family cytokines in cells expressing appro...
(A) Naïve OT-I CD8+ T cells were labelled with cell trace violet, activated in vitro with SIINFEKL p...
Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cell...
Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cell...
<p>WT, TNF<sup>-/-</sup> and TNFR2<sup>-/-</sup> OT-I cells recovered from infected lungs and spleen...
Interferon regulatory factor 3 (IRF3) is a transcription factor found in the cytoplasm of most nucle...
<p>Interfering with the IFNγ pathway in MSCs can partially restore Vδ2+ cell proliferation (A) Compa...
0 hour, is denoted by different color (green: downregulation, red: upregulation) at each timepoint i...
<p>Isolated CD4 (<b>a</b>) and CD8 (<b>b</b>) T cells from a healthy donor were cultured and treated...
<p><b>A.</b> Purified T cells were cultured in the presence or absence of 25 ng/ml IL-7 and IFN-γ co...
<p>Cells were collected from spleens of CD11c-<i>Ifnar1</i><sup>-/-</sup> mice and littermate contro...
<p>Cells were collected from spleens, MLNs, or Peyer’s patches of CD11c-<i>Ifnar1</i><sup>-/-</sup> ...
In response to acute virus infections, CD8(+) T cells differentiate to form a large population of sh...
(A) Western blot analysis of IFITM3 expression by CD8+ T cells before (0) and after in vitro activat...
<p>(<b>a–d</b>) CD8+ T cell proliferation under various stimuli. Cultures were incubated for 48 hour...
<p>Ifitm3 protein expression can also be induced by gp130-family cytokines in cells expressing appro...
(A) Naïve OT-I CD8+ T cells were labelled with cell trace violet, activated in vitro with SIINFEKL p...
Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cell...
Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cell...
<p>WT, TNF<sup>-/-</sup> and TNFR2<sup>-/-</sup> OT-I cells recovered from infected lungs and spleen...
Interferon regulatory factor 3 (IRF3) is a transcription factor found in the cytoplasm of most nucle...
<p>Interfering with the IFNγ pathway in MSCs can partially restore Vδ2+ cell proliferation (A) Compa...
0 hour, is denoted by different color (green: downregulation, red: upregulation) at each timepoint i...
<p>Isolated CD4 (<b>a</b>) and CD8 (<b>b</b>) T cells from a healthy donor were cultured and treated...
<p><b>A.</b> Purified T cells were cultured in the presence or absence of 25 ng/ml IL-7 and IFN-γ co...
<p>Cells were collected from spleens of CD11c-<i>Ifnar1</i><sup>-/-</sup> mice and littermate contro...
<p>Cells were collected from spleens, MLNs, or Peyer’s patches of CD11c-<i>Ifnar1</i><sup>-/-</sup> ...
In response to acute virus infections, CD8(+) T cells differentiate to form a large population of sh...