A high-throughput whole cell screen to identify inhibitors of <i>Mycobacterium tuberculosis</i> - Fig 4

Small molecule compound library screen: A selected library of 1105 small molecules from NIH-SRI/TAACF was screened in replicate experiments against (A) CHEAM3 or (B) DREAM8. The % inhibition for each compound was calculated. The results from the first and second runs are plotted on the x- and y-axis, respectively, for both strains. For each strain the Pearson coefficient of linear correlation between the two replicate data sets was calculated in Graphpad Prism and is shown in boxed text in the upper right corner of each plot. (C) The average % inhibition of CHEAM3 and DREAM8 growth was calculated and plotted on the x- and y- axis, respectively. The calculated Pearson co-efficient comparing the data generated from the two different strains is shown in boxed text in the upper right corner of the plot.