Serum levels of miR-122, miR-192, miR-29b, and miR-155 are elevated in patients with cholangiocarcinoma.
- Sven H. Loosen (5866946)
- Georg Lurje (5059535)
- Georg Wiltberger (533489)
- Mihael Vucur (180119)
- Alexander Koch (77280)
- Jakob N. Kather (6240275)
- Pia Paffenholz (6240278)
- Frank Tacke (170575)
- Florian T. Ulmer (6240281)
- Christian Trautwein (64353)
- Tom Luedde (180139)
- Ulf P. Neumann (5059544)
- Christoph Roderburg (180091)
Publication date
January 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Circulating levels of miR-122 (A), miR-192 (B), miR-29b (C) and miR-155 (D) are significantly elevated in CCA patients compared to healthy controls (U-Test). ROC curve analyses show a superior diagnostic potential for miR-122 and miR-192 regarding the discrimination between CCA patient and healthy controls (E, DeLong test). The combination of two miRNAs (miR-122 and miR-192) has a superior diagnostic potential compared to either miRNA alone (F). MiR-122 has a significantly higher AUC value compared to CA19-9 (p = 0.006) and CEA (pDeLong test). Serum levels of miR-122, miR-192 and miR-29b show a significant positive correlation with each other (H).</p
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