Admixture of HLA alleles associated with MS.
- Calvin Chi (6240473)
- Xiaorong Shao (2872574)
- Brooke Rhead (5917274)
- Edlin Gonzales (6240476)
- Jessica B. Smith (6240479)
- Anny H. Xiang (830200)
- Jennifer Graves (3459170)
- Amy Waldman (3411092)
- Timothy Lotze (4268935)
- Teri Schreiner (6240482)
- Bianca Weinstock-Guttman (105396)
- Gregory Aaen (6240485)
- Jan-Mendelt Tillema (6240488)
- Jayne Ness (6240491)
- Meghan Candee (6240494)
- Lauren Krupp (3449978)
- Mark Gorman (6240497)
- Leslie Benson (6240500)
- Tanuja Chitnis (236410)
- Soe Mar (6240503)
- Anita Belman (6240506)
- Theron Charles Casper (6240509)
- John Rose (33471)
- Manikum Moodley (6240512)
- Mary Rensel (6240515)
- Moses Rodriguez (156032)
- Benjamin Greenberg (121109)
- Llana Kahn (6240518)
- Jennifer Rubin (6240521)
- Catherine Schaefer (488200)
- Emmanuelle Waubant (356483)
- Annette Langer-Gould (6240524)
- Lisa F. Barcellos (156134)
Publication date
January 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Ancestry was inferred for MS-associated HLA alleles that passed QC using RFMix. MS-associated alleles were significant at the nominal level (p 2 > 0.80, and had minor allele frequency greater than 0.005. Other than HLA-B*55:01 in (A) African Americans, HLA-DRB1*15:01, HLA-DRB1*16:02, HLA-DRB1*01:01, HLA-DRB1*14:02, HLA-A*01:01 in (B) Hispanics, and HLA-B*27:05 and HLA-C*03:04 in (C) Asian Americans, HLA alleles associated with MS are cosmopolitan.</p
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