Hierarchical clustering of cell lines according to predicted signaling protein recruitment.

Heatmap colors indicate the ratio, derived from simulation results, of the number of bound molecules of a given protein (corresponding to protein name on the x-axis) divided by the total number of IGF1R molecules. As multiple copies of a protein can be bound to one IGF1R molecule, the ratio can be greater than one. Cell lines indicated (on the y-axis) include the tissue of origin or type of cancer followed by an underscore and the cell line name. OVAR = ovarian cancer, NSCLC = non-small cell lung cancer, MELAN = melanoma, CERV = cervical cancer, CNS = central nervous system cancer, LEUK = leukemia. For those cell lines evaluated in multiple studies (A549, HeLa S3, and MCF7), the proteomics data from Geiger et al. is indicated with “_G” following the cell line name, the data for the NCI-60 panel from Gholami et al. with the suffix “_N”, and the data from Kulak et al. with “_K”.