2,5-Diketopiperazines were prepared and characterized where one of the amino acids is (2S,3R,4R,5S)-3,4,5-trihydroxypipecolic acid. The protected pipecolic acid was synthesized from a selectively protected deoxynojirimycin derivative. The ring closure to give the diketopiperazines, from the dipeptides, was performed by nucleophilic attack of the amino function of the pipecolic acid moiety onto the carbonyl group of the methyl esters. </p
The efficient syntheses of substituted oxopiperazines from naturally occurring amino acids have been...
Amino acid derived spirocyclic 2,6-dioxopiperazines are easily and regioselectively opened by base-p...
Chiral 3,4-dibenzyloxy-5-hydroxymethyl-2-thiazolylpyrrolidines under Mitsunobu conditions (R-OH, Ph...
Diketopiperazines were formed in good yields on deprotection of N-protected dipeptide esters contain...
Diketopiperazines were formed in good yields on deprotection of N-protected dipeptide esters contain...
A variety of ring-opening reactions of pyroglutamic diketopiperazine at both the five-membered and s...
This article focuses on our investigation of the molecular structure characteristics of diketopipera...
N-Deprotection of Z- and Boc-aminomethylene pseudodipeptide methyl esters yielded not only the expec...
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 m...
This thesis describes the development of four synthetic routes towards the syntheses of N, N' ethyle...
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 m...
This work describes the synthesis in Solution of a series of related diketopiperazines with potentia...
Chiral spirocyclic 2,6-dioxopiperazines were synthesized from amino acid derived α-quaternary α-amin...
The synthesis of 1,3,6-trisubstituted-2,5-diketopiperazine scaffolds bearing up to three 'clickable'...
Cyclic dipeptides, often found in nature, are formed by linking amino-terminus of a linear dipeptide...
The efficient syntheses of substituted oxopiperazines from naturally occurring amino acids have been...
Amino acid derived spirocyclic 2,6-dioxopiperazines are easily and regioselectively opened by base-p...
Chiral 3,4-dibenzyloxy-5-hydroxymethyl-2-thiazolylpyrrolidines under Mitsunobu conditions (R-OH, Ph...
Diketopiperazines were formed in good yields on deprotection of N-protected dipeptide esters contain...
Diketopiperazines were formed in good yields on deprotection of N-protected dipeptide esters contain...
A variety of ring-opening reactions of pyroglutamic diketopiperazine at both the five-membered and s...
This article focuses on our investigation of the molecular structure characteristics of diketopipera...
N-Deprotection of Z- and Boc-aminomethylene pseudodipeptide methyl esters yielded not only the expec...
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 m...
This thesis describes the development of four synthetic routes towards the syntheses of N, N' ethyle...
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 m...
This work describes the synthesis in Solution of a series of related diketopiperazines with potentia...
Chiral spirocyclic 2,6-dioxopiperazines were synthesized from amino acid derived α-quaternary α-amin...
The synthesis of 1,3,6-trisubstituted-2,5-diketopiperazine scaffolds bearing up to three 'clickable'...
Cyclic dipeptides, often found in nature, are formed by linking amino-terminus of a linear dipeptide...
The efficient syntheses of substituted oxopiperazines from naturally occurring amino acids have been...
Amino acid derived spirocyclic 2,6-dioxopiperazines are easily and regioselectively opened by base-p...
Chiral 3,4-dibenzyloxy-5-hydroxymethyl-2-thiazolylpyrrolidines under Mitsunobu conditions (R-OH, Ph...
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