Lapatinib does not suppress T lymphocyte activation or function.
- Loral E. Showalter (4170238)
- Crystal Oechsle (6243821)
- Nirmala Ghimirey (6243824)
- Chase Steele (6243827)
- Brian J. Czerniecki (285700)
- Gary K. Koski (285702)
Publication date
January 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
A) IFN-γ ELISPOT assayof unfractionated human PBMCs from four unique donors stimulated with MHC class I recall peptides or tetanus toxoid protein in the presence of 2μM lapatinib. B) Composite data of the number of IFN-ɣ spot forming cells(normalized to control)from the same four donors. C) Flow cytometry analysis of allogenic DC:T cell co-cultures from three unique allogeneic stimulator:responder pairs with staining for CD4 (x axes) and CD69 (y axes). Percentage values indicate proportion of double-positive cells. D)ELISA analysis of IFN-ɣ production from four unique allogeneic stimulator:responder pairs in the presence or absence of lapatinib.</p
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