(A) The expression of the C. elegans immune effector genes irg-4, irg-5, drd-50, mul-1 and irg-6 were analyzed by qRT-PCR in wild-type animals, pmk-1(km25), nhr-86(tm2590), and pmk-1(km25); nhr-86(tm2590) double mutants, each exposed to either R24 or the control for approximately 18 hours. Data for drd-50, mul-1 and irg-6 are shown in S5A Fig. Data are the average of six independent replicates, each normalized to a control gene with error bars representing SEM. Data are presented as the value relative to the average expression from all replicates of the indicated gene in the baseline condition (wild-type animals exposed to control). The difference in induction of irg-4, irg-5, drd-50, mul-1 and irg-6 by R24 in wild-type animals compared to ...
Caenorhabditis elegans responds to pathogenic microorganisms by activating its innate immune system,...
<p><i>A</i>. Overlaps between <i>sek-1</i> (or <i>pmk-1)</i> targets (Troemel <i>et al</i>., 2006), ...
The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestina...
The basal expression of immune effectors such as irg-4, irg-5, mul-1 and drd-50 are ensured by p38 M...
(A)P. aeruginosa infection assays of C. elegans wild-type, nhr-86(tm2590) and nhr-86(ums12) treated ...
(A)C. elegans carrying either the Pirg-4(F08G5.6)::GFP or the Pirg-5(F35E12.5)::GFP immune reporter ...
<p>Six putative <i>C. elegans</i> immune effectors were analyzed by qRT-PCR in wild-type and <i>pmk-...
(A) All data from the mRNA-seq experiment are presented on scatter plots. Genes that were differenti...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
(A) Venn diagram showing the number of nhr-86-dependent, R24-induced genes in the mRNA-seq experimen...
The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathwa...
Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. Several conse...
Although Caenorhabditis elegans exhibits specific innate immune responses to microbial challenge, pa...
Caenorhabditis elegans responds to pathogenic microorganisms by activating its innate immune system,...
<p><i>A</i>. Overlaps between <i>sek-1</i> (or <i>pmk-1)</i> targets (Troemel <i>et al</i>., 2006), ...
The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestina...
The basal expression of immune effectors such as irg-4, irg-5, mul-1 and drd-50 are ensured by p38 M...
(A)P. aeruginosa infection assays of C. elegans wild-type, nhr-86(tm2590) and nhr-86(ums12) treated ...
(A)C. elegans carrying either the Pirg-4(F08G5.6)::GFP or the Pirg-5(F35E12.5)::GFP immune reporter ...
<p>Six putative <i>C. elegans</i> immune effectors were analyzed by qRT-PCR in wild-type and <i>pmk-...
(A) All data from the mRNA-seq experiment are presented on scatter plots. Genes that were differenti...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
(A) Venn diagram showing the number of nhr-86-dependent, R24-induced genes in the mRNA-seq experimen...
The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathwa...
Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. Several conse...
Although Caenorhabditis elegans exhibits specific innate immune responses to microbial challenge, pa...
Caenorhabditis elegans responds to pathogenic microorganisms by activating its innate immune system,...
<p><i>A</i>. Overlaps between <i>sek-1</i> (or <i>pmk-1)</i> targets (Troemel <i>et al</i>., 2006), ...
The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestina...