(A)P. aeruginosa infection assays of C. elegans wild-type, nhr-86(tm2590) and nhr-86(ums12) treated with R24 or 1% DMSO (control) are shown. The difference in susceptibility to P. aeruginosa between R24-exposed wild-type and each of the mutant animals is significant (pS4A Table. Significance was determined using Kaplan-Meier survival curves and log-rank tests. (B) C. elegans carrying the Phsp-4::GFP reporter were exposed to the indicated RNAi bacteria and transferred at the L4 stage to media supplemented with either R24 or control for approximately 18 hours. Scale bar equals 100 μm. (C) qRT-PCR was used to measure the spliced (active) and total xbp-1 mRNA in animals of the indicated genotype exposed to R24 or control. Comparisons were calcu...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Worms were fed on HT115 bacteria transformed whether with L4440 vector that produces double-stranded...
(A) Venn diagram showing the number of nhr-86-dependent, R24-induced genes in the mRNA-seq experimen...
(A) The expression of the C. elegans immune effector genes irg-4, irg-5, drd-50, mul-1 and irg-6 wer...
(A)C. elegans carrying either the Pirg-4(F08G5.6)::GFP or the Pirg-5(F35E12.5)::GFP immune reporter ...
<p>Six putative <i>C. elegans</i> immune effectors were analyzed by qRT-PCR in wild-type and <i>pmk-...
(A) All data from the mRNA-seq experiment are presented on scatter plots. Genes that were differenti...
Caenorhabditis elegans responds to pathogenic microorganisms by activating its innate immune system,...
The basal expression of immune effectors such as irg-4, irg-5, mul-1 and drd-50 are ensured by p38 M...
<p>Synchronized L1 wild-type (N2) or transgenic strain (SAL105) larvae were pretreated without (0 µM...
C. elegans, a free-living nematode, forms an excellent model system to study severalaspects of biolo...
<p><i>P. aeruginosa</i> infection assays of <i>C. elegans</i> wild-type and mutant animals exposed t...
<p>(A–B) Median survival values (hours after transfer to <i>S. aureus</i>) representing at least two...
<p>(A) Fluorescence microscopy images of <i>C. elegans acIs101</i> animals, which express a <i>F35E1...
(A) Dose response curves to IVM in a larval development assay of nhr-8(ok186) in comparison to the w...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Worms were fed on HT115 bacteria transformed whether with L4440 vector that produces double-stranded...
(A) Venn diagram showing the number of nhr-86-dependent, R24-induced genes in the mRNA-seq experimen...
(A) The expression of the C. elegans immune effector genes irg-4, irg-5, drd-50, mul-1 and irg-6 wer...
(A)C. elegans carrying either the Pirg-4(F08G5.6)::GFP or the Pirg-5(F35E12.5)::GFP immune reporter ...
<p>Six putative <i>C. elegans</i> immune effectors were analyzed by qRT-PCR in wild-type and <i>pmk-...
(A) All data from the mRNA-seq experiment are presented on scatter plots. Genes that were differenti...
Caenorhabditis elegans responds to pathogenic microorganisms by activating its innate immune system,...
The basal expression of immune effectors such as irg-4, irg-5, mul-1 and drd-50 are ensured by p38 M...
<p>Synchronized L1 wild-type (N2) or transgenic strain (SAL105) larvae were pretreated without (0 µM...
C. elegans, a free-living nematode, forms an excellent model system to study severalaspects of biolo...
<p><i>P. aeruginosa</i> infection assays of <i>C. elegans</i> wild-type and mutant animals exposed t...
<p>(A–B) Median survival values (hours after transfer to <i>S. aureus</i>) representing at least two...
<p>(A) Fluorescence microscopy images of <i>C. elegans acIs101</i> animals, which express a <i>F35E1...
(A) Dose response curves to IVM in a larval development assay of nhr-8(ok186) in comparison to the w...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host r...
Worms were fed on HT115 bacteria transformed whether with L4440 vector that produces double-stranded...
(A) Venn diagram showing the number of nhr-86-dependent, R24-induced genes in the mRNA-seq experimen...