Evolutionary age of affected genes.

Ratios of observed versus expected number of genes from each gene evolutionary age that contain deletions overlapping with exons, including partial and whole gene CNVs (A) or intronic deletions (B). Expected values were calculated with 10,000 random permutations using a global background model. Red asterisks mark the significantly enriched groups of genes. Significance: * for PS8 Fig. (D) Percentage of highly stratified variants (HSV, maximum Vst > 0.2) in each age group and by type of overlap with the gene. The absolute number of deletions is indicated above each bar.