Additional file 1: of p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling

Figure S1. Molecular characteristics of the luminal subsets isolated from control and K5Cre;Trp53F/F adult virgin mice using ICAM-1. (a) Heat map showing hierarchical clustering of the 7 Lu-pos and Lu-neg cell samples analyzed. A total of 1115 genes with a minimal intensity level of 7 displayed a fold-change ≥ 1.5. (b) Expression heat map of the top 100 modulated genes. (c) Venn diagram showing the number of activated p53 target genes differentially expressed in Lu-pos and Lu-neg cell populations. (d) Relative expression levels of p53 target genes in Lu-pos cells isolated from control and K5Cre;Trp53F/F mutant adult virgin mice. The qPCR data are shown as mean ratios ± SEM between gene expression levels in mutant and control Lu-pos cells from at least 3 separate preparations. *p ≤ 0.05, **p ≤ 0.01. (PDF 8195 kb