VEGFq induced inhibition of cell growth can be partially rescued by recombinant VEGF and the absence of cell cycle changes.

(A) The effect of treatment of A549 cells with recombinant VEGF (1–50 ng/ml) with and without VEGFq pretreatment on cell proliferation after 144h by MTT assay. Bars represent mean±SEM absorbance of three separate determinations. * indicates (p<0.05) compared to untreated cells. Results show that addition of recombinant VEGF to VEGFq-treated cells significantly diminishes the growth inhibitory effect of VEGFq treatment. (B) Flow cytometry analysis of cell cycle for A549 cells treated with VEGFq and MutVEGF. No changes in the cell cycle were noted.