Microglial immunostaining.
- Rachel Waller (4985063)
- Lynne Baxter (6265391)
- Daniel J. Fillingham (6265394)
- Santiago Coelho (6265397)
- Jose M. Pozo (4107334)
- Meghdoot Mozumder (6265400)
- Alejandro F. Frangi (651644)
- Paul G. Ince (251345)
- Julie E. Simpson (694583)
- J. Robin Highley (745721)
Publication date
January 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Iba-1 (A-C), CD68 (D-F) and MHCII (G-I) protein expression within the control, NAWM and DSCL cases. Control WM showed a regular distribution of Iba-1 positive ramified microglia (A) in contrast to the little CD68 and MHCII immunostaining in control WM (D & G). Within NAWM an increase in immunoreactivity was evident across all three microglial markers (B,E,H). Within DSCL, Iba-1 and MHCII immunostaining highlighted both ramified and amoeboid microglia (C & I). In contrast CD68 immunostaining highlighted amoeboid microglia (F). Scale bar = 100μm. NAWM: normal appearing white matter, DSCL: deep subcortical lesion, WM: white matter, MHCII: major histocompatibility complex II.</p
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