The panels on the diagonal shows the relative growth reduction of E. coli grown with individual antibiotics (Table 1) at 13 doses (dots). Doses for each drug were spaced linearly such that the halfway effect D50 is approximately at the middle dose. These dose-response curves are well described by Hill curves (solid line). The off-diagonal panels show the two-drug responses for all 45 pairs of the ten drugs, at 13 dose combinations (dots). For example, the panel located at the 4th row and 7th column shows the pair response of drug 4(CHL) and drug 7(MOX) (also shown in the inset figure). We mixed the drugs at the 13 doses used for the single-drug dose-response curves, thus diluting each drug by a factor of two. The pair response curves were u...
For each plot, top panel: bacterial densities; bottom panel: phage densities. Blue boxes: treatment ...
Escherichia coli strains that were susceptible to multiple antibiotics were exposed to suprainhibito...
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome res...
(A) The response curves for all 115 combinations (dots) compared to the dose model predictions (soli...
<p>Viable cell densities of <i>E. coli</i> following 6 hours of exposure to equivalent cidal concent...
Drugs are commonly used in combinations larger than two for treating bacterial infection. However, i...
The purpose of this thesis was to: (1) explore the in vitro dose-response relationship between genta...
International audienceThe time killing curves of five strains of Escherichia coli (ATCC 25922, ATCC ...
(A) The response curves for all 9 combinations (dots) compared to the dose model predictions (solid ...
Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infecti...
<p>(a) Empirical dose-response checkerboards show population density data on the <i>z</i>-axis versu...
Since the 1950s, antibiotics have been used to treat bacterial infections in humans, pets, and lives...
International audienceThe time killing curves of three strains of E. coli (CIP54117, ATCC25922 and A...
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome res...
Due to high rates of emerging antibiotic resistant bacteria, research into combatting these “superbu...
For each plot, top panel: bacterial densities; bottom panel: phage densities. Blue boxes: treatment ...
Escherichia coli strains that were susceptible to multiple antibiotics were exposed to suprainhibito...
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome res...
(A) The response curves for all 115 combinations (dots) compared to the dose model predictions (soli...
<p>Viable cell densities of <i>E. coli</i> following 6 hours of exposure to equivalent cidal concent...
Drugs are commonly used in combinations larger than two for treating bacterial infection. However, i...
The purpose of this thesis was to: (1) explore the in vitro dose-response relationship between genta...
International audienceThe time killing curves of five strains of Escherichia coli (ATCC 25922, ATCC ...
(A) The response curves for all 9 combinations (dots) compared to the dose model predictions (solid ...
Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infecti...
<p>(a) Empirical dose-response checkerboards show population density data on the <i>z</i>-axis versu...
Since the 1950s, antibiotics have been used to treat bacterial infections in humans, pets, and lives...
International audienceThe time killing curves of three strains of E. coli (CIP54117, ATCC25922 and A...
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome res...
Due to high rates of emerging antibiotic resistant bacteria, research into combatting these “superbu...
For each plot, top panel: bacterial densities; bottom panel: phage densities. Blue boxes: treatment ...
Escherichia coli strains that were susceptible to multiple antibiotics were exposed to suprainhibito...
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome res...