Glutamate, succinate, and palmitoyl-L-carnitine-supported oxygen consumption decreased mildly with HFD, but recovered over time.
- Pamela A. Kakimoto (6294206)
- Bruno Chausse (699726)
- Camille C. Caldeira da Silva (364723)
- José Donato Júnior (6294209)
- Alicia J. Kowaltowski (284269)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Oxygen consumption rates (OCR) of isolated mitochondria from livers after 2, 4 and 8 weeks of high-fat feeding. (A, B and G) Glutamate, malate and succinate were used as substrates. (D, F and H) Palmitoyl-carnitine and malate as substrates. “State 3” is the oxygen consumption rate in presence of ADP; “state 4” represents oxygen consumption measured in the presence of ATP synthase inhibitor oligomycin. Data are means + SEM, n = 5–9. Unfilled circles represent a biological replicate. Differences among means were evaluated by two-way ANOVA. * = p < 0.05 in Sidak’s posttest analysis.</p
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