Nr2f proteins are required to limit ventricular CMs.
- Tracy E. Dohn (6298088)
- Padmapriyadarshini Ravisankar (798448)
- Fouley T. Tirera (6298091)
- Kendall E. Martin (6298094)
- Jacob T. Gafranek (6298097)
- Tiffany B. Duong (6298100)
- Terri L. VanDyke (6298103)
- Melissa Touvron (6298106)
- Lindsey A. Barske (6298109)
- J. Gage Crump (135956)
- Joshua S. Waxman (443499)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Schematic of tcf21:CreERT2 recombinase and myl7 promoter driven Cre-mediated color-switch transgenic lines used. (B-E) Hearts with labeled CMs in nr2f1a-2ctrl and nr2f1a-2mut embryos carrying the tcf21:CreERT2; myl7:CsY transgenes. Labeled CMs–green. Cardiac muscles (MHC)–red. Atrium (AMHC)–blue. Images are frontal views. (F) Mean number of ventricular CMs labeled in nr2f1a-2wt (n = 98) and nr2f1a-2mut (n = 24) embryos. (G) Mean number of ventricular CMs labeled when more than one labeled ventricular CM was found in nr2f1a-2wt (n = 38) and nr2f1a-2mut (n = 14) embryos.</p
Add to ORKG