MOESM4 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers

Scarpati G.
Baldassarre D.
Tripepi G.
Boffardi M.
Piazza O.

January 2021

Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compa...

Data from: IgM-enriched immunoglobulin attenuates systemic endotoxin activity in early severe sepsis: a before-after cohort study

Wand, Saskia
Klages, Matthias
Kirbach, Christin
Warszawska, Joanna
Meybohm, Patrick
Zacharowski, Kai
Koch, Alexander

August 2016

Introduction: Sepsis remains associated with a high mortality rate. Endotoxin has been shown to infl...

Effects of IgM-enriched immunoglobulin therapy in septic-shock-induced multiple organ failure: Pilot study

Toth, Ildiko
Mikor, Andras
Leiner, Tamas
Molnar, Zsolt
Bogar, Lajos
Szakmany, Tamas

August 2013

Mortality due to septic-shock–induced respiratory failure remains high. A recent meta-analysis sugge...

MOESM5 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 5: Figure S2. Subgroup analysis-severity scores, evaluating survival benefit of intr...

MOESM1 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 1: Table S1. Primary and secondary outcomes of the studies included in the meta-anal...

MOESM6 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 6: Figure S3. Forest plot for ventilation free days (VFDs) after intravenous IgM-enr...

MOESM2 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 2: Table S2. Quality Assessment for Randomized Controlled Trials

MOESM3 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 3: Table S3. Quality Assessment With NewcastleâOttawa Scale for cohort study

The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui
Xuxia Wei
Haijin Lv
Yuntao Li
Ping Li
Zhen Chen
Genglong Liu

February 2019

Abstract Background Sepsis is characterized by a complex immune response. This meta-analysis evaluat...

Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

January 2021

5Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response t...

MOESM1 of Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients

Giorgio Berlot (6067076)
Claudio Vassallo (6067079)
Nicola Busetto (6067082)
Margarita Nieto Yabar (6067085)
Tatiana Istrati (6067088)
Silvia Baronio (6067091)
Giada Quarantotto (6067094)
Mattia Bixio (6067097)
Giulia Barbati (4093843)
Roberto Dattola (6067100)
Irene Longo (6067103)
Antonino Chillemi (6067106)
Alice Scamperle (6067109)
Fulvio Iscra (1006)
Ariella Tomasini (6067112)

December 2018

Additional file 1. Adjustment of analyses for severity and periods of enrollment and subgroup analys...

Efficacy of an IgM preparation in the treatment of patients with sepsis: a double-blind randomized clinical trial in a pediatric intensive care unit

Kola, Ermira
Çelaj, Ermela
Bakalli, Iliriana
Lluka, Robert
Kuli-Lito, Gjeorgjina
Sallabanda, Sashenka

December 2015

Aim: Additional treatments for sepsis to be administered alongside the standard therapy recommended ...

The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease

Pedro Amoedo Fernandes
Flávia Tobaldini Russo
Lucas Augusto Monetta da Silva
Lafayete William Ferreira Ramos
Aline de Almeida Simões
Larissa Yukari Okada
Jamilla Neves Cavalcante
Maricy Almeida Viol Ferreira Lopes
Maria Cristina Martins de Almeida Macedo
Roberto Luiz da Silva

April 2021

Background: Patients with hematological disease are 15 times more likely to develop sepsis than the ...

Intravenous immunoglobulin in septic shock: review of the mechanisms of action and meta-analysis of the clinical effectiveness

Busani, S
Cavazzuti, I
Girardis, M.
DAMIANI, ELISA
DONATI, Abele

January 2016

Sepsis is characterized by a complex immune response. In this study we aimed to provide a review of ...

Bench-to-bedside review:Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective

Shankar-Hari, Manu
Spencer, Jo
Sewell, William A
Rowan, Kathryn M
Singer, Mervyn

March 2012

Sepsis represents a dysregulated host response to infection, the extent of which determines the seve...

Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers

Scarpati G.
Baldassarre D.
Tripepi G.
Boffardi M.
Piazza O.

January 2021

Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compa...

Data from: IgM-enriched immunoglobulin attenuates systemic endotoxin activity in early severe sepsis: a before-after cohort study

Wand, Saskia
Klages, Matthias
Kirbach, Christin
Warszawska, Joanna
Meybohm, Patrick
Zacharowski, Kai
Koch, Alexander

August 2016

Introduction: Sepsis remains associated with a high mortality rate. Endotoxin has been shown to infl...

Effects of IgM-enriched immunoglobulin therapy in septic-shock-induced multiple organ failure: Pilot study

Toth, Ildiko
Mikor, Andras
Leiner, Tamas
Molnar, Zsolt
Bogar, Lajos
Szakmany, Tamas

August 2013

Mortality due to septic-shock–induced respiratory failure remains high. A recent meta-analysis sugge...

MOESM5 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 5: Figure S2. Subgroup analysis-severity scores, evaluating survival benefit of intr...

MOESM1 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 1: Table S1. Primary and secondary outcomes of the studies included in the meta-anal...

MOESM6 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 6: Figure S3. Forest plot for ventilation free days (VFDs) after intravenous IgM-enr...

MOESM2 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 2: Table S2. Quality Assessment for Randomized Controlled Trials

MOESM3 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui (198388)
Xuxia Wei (6309782)
Haijin Lv (6309785)
Yuntao Li (583853)
Ping Li (31981)
Zhen Chen (129176)
Genglong Liu (6309788)

February 2019

Additional file 3: Table S3. Quality Assessment With NewcastleâOttawa Scale for cohort study

The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Jie Cui
Xuxia Wei
Haijin Lv
Yuntao Li
Ping Li
Zhen Chen
Genglong Liu

February 2019

Abstract Background Sepsis is characterized by a complex immune response. This meta-analysis evaluat...

Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

January 2021

5Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response t...

MOESM1 of Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients

Giorgio Berlot (6067076)
Claudio Vassallo (6067079)
Nicola Busetto (6067082)
Margarita Nieto Yabar (6067085)
Tatiana Istrati (6067088)
Silvia Baronio (6067091)
Giada Quarantotto (6067094)
Mattia Bixio (6067097)
Giulia Barbati (4093843)
Roberto Dattola (6067100)
Irene Longo (6067103)
Antonino Chillemi (6067106)
Alice Scamperle (6067109)
Fulvio Iscra (1006)
Ariella Tomasini (6067112)

December 2018

Additional file 1. Adjustment of analyses for severity and periods of enrollment and subgroup analys...

Efficacy of an IgM preparation in the treatment of patients with sepsis: a double-blind randomized clinical trial in a pediatric intensive care unit

Kola, Ermira
Çelaj, Ermela
Bakalli, Iliriana
Lluka, Robert
Kuli-Lito, Gjeorgjina
Sallabanda, Sashenka

December 2015

Aim: Additional treatments for sepsis to be administered alongside the standard therapy recommended ...

The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease

Pedro Amoedo Fernandes
Flávia Tobaldini Russo
Lucas Augusto Monetta da Silva
Lafayete William Ferreira Ramos
Aline de Almeida Simões
Larissa Yukari Okada
Jamilla Neves Cavalcante
Maricy Almeida Viol Ferreira Lopes
Maria Cristina Martins de Almeida Macedo
Roberto Luiz da Silva

April 2021

Background: Patients with hematological disease are 15 times more likely to develop sepsis than the ...

Intravenous immunoglobulin in septic shock: review of the mechanisms of action and meta-analysis of the clinical effectiveness

Busani, S
Cavazzuti, I
Girardis, M.
DAMIANI, ELISA
DONATI, Abele

January 2016

Sepsis is characterized by a complex immune response. In this study we aimed to provide a review of ...

Bench-to-bedside review:Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective

Shankar-Hari, Manu
Spencer, Jo
Sewell, William A
Rowan, Kathryn M
Singer, Mervyn

March 2012

Sepsis represents a dysregulated host response to infection, the extent of which determines the seve...

Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers

Scarpati G.
Baldassarre D.
Tripepi G.
Boffardi M.
Piazza O.

January 2021

Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compa...

Data from: IgM-enriched immunoglobulin attenuates systemic endotoxin activity in early severe sepsis: a before-after cohort study

Wand, Saskia
Klages, Matthias
Kirbach, Christin
Warszawska, Joanna
Meybohm, Patrick
Zacharowski, Kai
Koch, Alexander

August 2016

Introduction: Sepsis remains associated with a high mortality rate. Endotoxin has been shown to infl...

Effects of IgM-enriched immunoglobulin therapy in septic-shock-induced multiple organ failure: Pilot study

Toth, Ildiko
Mikor, Andras
Leiner, Tamas
Molnar, Zsolt
Bogar, Lajos
Szakmany, Tamas

August 2013

Mortality due to septic-shock–induced respiratory failure remains high. A recent meta-analysis sugge...

MOESM4 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Abstract

Extracted data

MOESM4 of The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Abstract

Extracted data

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