The loss of FTO leads to impairment of neuronal differentiation in the dentate gyrus of the hippocampus.

(A-B) Representative overview images of whole dentate gyrus of the hippocampus of Fto+/+ and Fto-/- mice.(C-H) Detailed representative immunofluorescence staining images show DCX+ neurons of the dentate gyrus in the hippocampus of Fto+/+ and Fto-/- mice. (I) Quantitative analysis indicated that Fto-/- mice had a lower percentage of DCX+ neurons per total cell number in the dentate gyrus than Fto+/+ mice, n = 4 Fto+/+ / 5 Fto-/-. Data are presented as mean ± S.E.M., unpaired t-test, **P < 0.01.