Post-transplant APRIL/BLyS blockade significantly depleted B lymphocytes from splenic germinal centers compared to pre-transplant treatment.
- Natalie M. Bath (6316517)
- Xiang Ding (607469)
- Nancy A. Wilson (36137)
- Bret M. Verhoven (6316520)
- Brittney A. Boldt (6316523)
- Adarsh Sukhwal (6316526)
- Shannon R. Reese (6316529)
- Sarah E. Panzer (6316532)
- Arjang Djamali (6316535)
- Robert R. Redfield III (6316538)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Top row (left to right): sensitized transplant control group (G4); sensitized pre-transplant APRIL/BLyS blockade group (G5). Bottom row (left to right): sensitized post-transplant APRIL/BLyS blockade group (G6); sensitized both pre- post-transplant APRIL/BLyS blockade (G7). (A) Sensitized transplant control animals (G4) demonstrated normal architecture of germinal centers (outlined). (B) Densitometry using anti-PAX5 antibody to detect B lymphocytes in splenic germinal centers. Graph depicts percentage of total area of spleen staining for anti-PAX5.</p
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