Additional file 7: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer
- Emanuela Brunetto (6332447)
- Lucia De Monte (6332450)
- Gianpaolo Balzano (3332637)
- Barbara Camisa (6332453)
- Vincenzo Laino (6332456)
- Michela Riba (438649)
- Silvia Heltai (6246830)
- Marco Bianchi (1781833)
- Claudio Bordignon (78315)
- Massimo Falconi (287022)
- Attilio Bondanza (23998)
- Claudio Doglioni (249841)
- Maria Protti (6332459)
Publication date
February 2019
DOIAbstract
Figure S7. Proposed model of crosstalk within the tumor microenvironment leading to TSLP secretion by CAFs and Th2 inflammation. a Inflammatory cytokines are released from dying/dead tumor cells. b Tumor cells release ASC that activates TAMs to secrete IL-1β (c). d Tumor cell- and TAM-derived IL-1ι and IL-1β, respectively, induce TSLP secretion by CAFs. e TSLP activates resident DCs with Th2 polarizing capability. Pharmacological molecules able to interfere with these mechanisms are indicated in red. (DOCX 2538 kb
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