Lower frequency of glutamatergic mEPSCs but no alteration in mEPSC amplitude and kinetics in cortical pyramidal neurons exposed to Y-P30.

(A) Sample traces of miniature excitatory postsynaptic currents (mEPSCs) recorded from DIV 15–17 dissociated cortical neurons under control conditions and following chronic exposure to Y-P30. (B) Recordings from neurons grown in the presence of Y-P30 revealed significantly lower mean mEPSC frequency, but not (C) mEPSC amplitude, (D) mEPSC rise time, or (E) mEPSC decay time. (F) Chronic exposure to Y-P30 did not have a significant effect on cell membrane capacitance. *p < 0.05, Mann-Whitney U-test.