Illustration of the canonical JAK/STAT pathway.
- Priyata Kalra (6331118)
- Julian Brandl (3840103)
- Thomas Gaub (223638)
- Christoph Niederalt (535381)
- Jörg Lippert (124210)
- Sven Sahle (222858)
- Lars Küpfer (6331121)
- Ursula Kummer (437648)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
The key steps of the pathway in response to IFN-α are highlighted here. IFN binds to the receptor and activates JAK1 and TYK2, which subsequently activate the STATs in the cytoplasm, all by phosphorylation. The phosphorylated STATs and IRF9 form the transcription complex ISGF3, which translocates to the nucleus, where it activates hundreds of ISGs, including IRF9, Mx2 and SOCS1.</p
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