Additional file 4: of Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma

Figure S4. Expression of SGmic genes in glioma-associated microglia as compared to healthy microglia in RNA sequencing datasets derived from healthy, RCAS glioma or GL261 glioma mice. (a) The log-fold change expression of SGmic genes (P2ry13, P2ry12, Gpr34, Slc2a5, Siglec-H, Olfml3, Tmem119, Fcrls) in glioma-associated microglia isolated from experimental RCAS tumors compared to microglia isolated from healthy control brains is shown. Expression data were extracted from RNA sequencing data generated by our group. (b) The log-fold change expression of SGmic genes (P2ry13, P2ry12, Gpr34, Slc2a5, Siglec-H, Olfml3, Tmem119, Fcrls) in glioma-associated microglia isolated from RCAS tumors compared to microglia isolated from healthy control brains is shown. Expression data were extracted from published RNA sequencing data [5]. (c) Graph shows the log-fold change expression of SGmic genes (P2ry13, P2ry12, Gpr34, Slc2a5, Siglec-H, Olfml3, Tmem119, Fcrls) in glioma-associated microglia isolated from GL261 tumors as compared to microglia isolated from healthy control brains. Expression data were extracted from published RNA sequencing data [5]. (PDF 394 kb