Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia - Fig 2
- Laurent M. A. Favié (5118422)
- Floris Groenendaal (283739)
- Marcel P. H. van den Broek (6336557)
- Carin M. A. Rademaker (572447)
- Timo R. de Haan (390927)
- Henrica L. M. van Straaten (6336560)
- Peter H. Dijk (410312)
- Arno van Heijst (2736190)
- Jeroen Dudink (450262)
- Koen P. Dijkman (6336563)
- Monique Rijken (6336566)
- Inge A. Zonnenberg (6336569)
- Filip Cools (6336572)
- Alexandra Zecic (6336575)
- Johanna H. van der Lee (390932)
- Debbie H. G. M. Nuytemans (578093)
- Frank van Bel (175638)
- Toine C. G. Egberts (447045)
- Alwin D. R. Huitema (6336578)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Average predicted morphine clearance over time before, during and after TH for neonates with BW 3.5 and GA 36, 38, 40 and 42 weeks, respectively (left) and for neonates with GA 40 weeks and BW 2.5, 3.0, 3.5 and 4.0 kg, respectively (right). Solid vertical lines represent the start and end of TH (33.5°C) simulated between 5h and 77h after birth; dashed vertical line indicates the return to normothermia (36.5°C) with rewarming simulated at. 0.4°C/h; TH = therapeutic hypothermia, BW = birth weight GA = gestational age.</p
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