Genes in modules were analyzed by KEGG pathway.

(A-D) represent MEblue, MEgreenyellow MEyellow, MEblack, and MEsalmon modules, respectively. the ordinate represents KEGG pathways and the abscissa represents Rich factor. Rich factor is the ratio of differentially expressed genes (DEGs) enriched in this pathway to the total number of annotated genes in the pathway. The size of the points indicates the number of DEGs in each pathway and the colors of the dots represent different p-values; the closer you get to red, the more significant the enrichment.