Both CRL4s and PCNA mediated interactions are required for stabilizing ESCO2 on chromatin.
- Haitao Sun (504648)
- Jiaxin Zhang (1836484)
- Siyu Xin (6377648)
- Meiqian Jiang (6377651)
- Jingjing Zhang (163589)
- Zhen Li (49109)
- Qinhong Cao (735648)
- Huiqiang Lou (735568)
Publication date
March 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) ESCO2 mutants display compromised SMC3 acetylation and thereby cohesion establishment. ESCO2 alleles: PIP, ESCO2-Q374AI376AI377A; LG, ESCO2-L415DG417D; PIP-LG, ESCO2-Q374AI376AI377A-L415DG417D. Quantitation from three biological repeats is shown for SMC3ac (middle) and cohesion efficiency (lower). The statistical significance was calculated via student’s t-test, *PMMS22L ligases. This is required for efficient SMC3 acetylation of the pre-loaded cohesin ring, which triggers the establishment of cohesion between two newly synthesized sister chromatids.</p
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