Additional file 3: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

Publication date

February 2019

DOI

10.6084/m9.figshare.7750670.v1

Abstract

Figure S2. Lnc-PDZD7 increase the CSC markers in HCC cells. Expression of CD133, OCT4, NANOG, SOX2 were examined by qRT-PCR in siLnc-scr and siLnc-PDZD7 transfected HepG2 cells and Lnc-PDZD7 and Lnc-vec transfected Bel-7402 cells (*Pâ<â0.05). (TIF 1203 kb

Extracted data

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Additional file 3: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

Open link

Publication date

February 2019

DOI

10.6084/m9.figshare.7750670.v1

Abstract

Extracted data

Min-Hui Yang (503238)
Li Zhao (147498)
Lan Wang (85307)
Wen Ou-Yang (6417875)
Sha-Sha Hu (6417878)
Wen-Lu Li (6417881)
Mei-Ling Ai (6417884)
Yi-Qing Wang (5515640)
Yue Han (560788)
Ting-Ting Li (32847)
Yan-Qing Ding (458014)
Shuang Wang (46453)

March 2019

Figure S4. HOXD-AS1 regulates HOXD3 expression through cooperating with PRC2 complex. (a) RIP assays...

Additional file 2: Figure S1. of Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

Xuening Ji (3540773)
Shi Jin (641785)
Xiaotong Qu (3427790)
Kejun Li (171059)
Hongjiang Wang (171043)
Hui He (356808)
Fuchao Guo (3540770)
Lei Dong (165252)

October 2015

A and B, qChIP was performed to assess H3K27me3 occupancy in HCC L02-pBabe-KDM5C and its control cel...

Additional file 2: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S1. Prognostic value of CD73 in subgroups of HCC patients. (A) Kaplan–Meier analysis of TTR o...

Additional file 6: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S5. Lnc-PDZD7 negatively regulate ATOH8 expression in HCC spheres. Expression of ATOH8 were e...

Additional file 5: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S4. EZH2 is a functional downstream target of Lnc-PDZD7 in HCC cells. A, The mRNA level of EZ...

Additional file 1: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S1. Heatmap representation of 26 upregulated lncRNAs in HCC tissues compared to para-tumorous...

Additional file 2: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Table S1. Multivariate survival analysis of five-year overall and relapse-free survival in 152 HCC p...

Additional file 4: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S3 EZH2 is a functional downstream target of miR-101. A, Lnc-PDZD7 was precipitated using a L...

Additional file 8: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S7. CD73 function in HCC depends on its enzymatic activity. (A) Proliferation capacity in the...

Additional file 6: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 3: of The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

Jin-lan Huang (5293874)
Shun-wang Cao (5293877)
Qi-shui Ou (5293883)
Bin Yang (103252)
Shi-hao Zheng (5293871)
Jing Tang (33607)
Jing Chen (4762)
Yan-wei Hu (5293880)
Lei Zheng (106363)
Qian Wang (32718)

May 2018

Figure S1. (a) Taking the differentially expressed mRNAs in our microarray analysis as input, the pa...

Additional file 7: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S6. Role of PI3K/AKT signaling in CD73 mediating HCC progression. (A) Expressions of EMT-rela...

Additional file 7: Figure S3. of STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

Hui Wang (30400)
Xisong Huo (4358206)
Xin-Rong Yang (202583)
Jia He (89641)
Lijun Cheng (3469445)
Na Wang (193263)
Xuan Deng (437960)
Haojie Jin (3821953)
Ning Wang (108353)
Cun Wang (283325)
Fangyu Zhao (163571)
Jingyuan Fang (426044)
Ming Yao (130901)
Jia Fan (178422)
Wenxin Qin (321934)

August 2017

Analysis for HOXD-AS1 expression and phosphorylated STAT3 in HCC tissues. (A) The transcriptional ex...

Additional file 7: of Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling

Min-Hui Yang (503238)
Li Zhao (147498)
Lan Wang (85307)
Wen Ou-Yang (6417875)
Sha-Sha Hu (6417878)
Wen-Lu Li (6417881)
Mei-Ling Ai (6417884)
Yi-Qing Wang (5515640)
Yue Han (560788)
Ting-Ting Li (32847)
Yan-Qing Ding (458014)
Shuang Wang (46453)

March 2019

Figure S5. HOXD3 is required for the HOXD-AS1-mediated progress of CRC in vitro. (a) Real-time PCR a...

Additional file 6: of Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin Î˛3 transcriptional activating and MAPK/AKT signalling

Min-Hui Yang (503238)
Li Zhao (147498)
Lan Wang (85307)
Wen Ou-Yang (6417875)
Sha-Sha Hu (6417878)
Wen-Lu Li (6417881)
Mei-Ling Ai (6417884)
Yi-Qing Wang (5515640)
Yue Han (560788)
Ting-Ting Li (32847)
Yan-Qing Ding (458014)
Shuang Wang (46453)

March 2019

Figure S4. HOXD-AS1 regulates HOXD3 expression through cooperating with PRC2 complex. (a) RIP assays...

Additional file 2: Figure S1. of Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

Xuening Ji (3540773)
Shi Jin (641785)
Xiaotong Qu (3427790)
Kejun Li (171059)
Hongjiang Wang (171043)
Hui He (356808)
Fuchao Guo (3540770)
Lei Dong (165252)

October 2015

A and B, qChIP was performed to assess H3K27me3 occupancy in HCC L02-pBabe-KDM5C and its control cel...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S1. Prognostic value of CD73 in subgroups of HCC patients. (A) Kaplan–Meier analysis of TTR o...

Additional file 6: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S5. Lnc-PDZD7 negatively regulate ATOH8 expression in HCC spheres. Expression of ATOH8 were e...

Additional file 5: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S4. EZH2 is a functional downstream target of Lnc-PDZD7 in HCC cells. A, The mRNA level of EZ...

Additional file 1: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S1. Heatmap representation of 26 upregulated lncRNAs in HCC tissues compared to para-tumorous...

Additional file 2: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Table S1. Multivariate survival analysis of five-year overall and relapse-free survival in 152 HCC p...

Additional file 4: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Yi Zhang (9093)
Bo Tang (23472)
Jun Song (19318)
Shuiping Yu (3575978)
Yang Li (7082)
Huizhao Su (6188948)
Songqing He (492664)

February 2019

Figure S3 EZH2 is a functional downstream target of miR-101. A, Lnc-PDZD7 was precipitated using a L...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S7. CD73 function in HCC depends on its enzymatic activity. (A) Proliferation capacity in the...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 3: of The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

Jin-lan Huang (5293874)
Shun-wang Cao (5293877)
Qi-shui Ou (5293883)
Bin Yang (103252)
Shi-hao Zheng (5293871)
Jing Tang (33607)
Jing Chen (4762)
Yan-wei Hu (5293880)
Lei Zheng (106363)
Qian Wang (32718)

May 2018

Figure S1. (a) Taking the differentially expressed mRNAs in our microarray analysis as input, the pa...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S6. Role of PI3K/AKT signaling in CD73 mediating HCC progression. (A) Expressions of EMT-rela...

Additional file 7: Figure S3. of STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

Hui Wang (30400)
Xisong Huo (4358206)
Xin-Rong Yang (202583)
Jia He (89641)
Lijun Cheng (3469445)
Na Wang (193263)
Xuan Deng (437960)
Haojie Jin (3821953)
Ning Wang (108353)
Cun Wang (283325)
Fangyu Zhao (163571)
Jingyuan Fang (426044)
Ming Yao (130901)
Jia Fan (178422)
Wenxin Qin (321934)

August 2017

Analysis for HOXD-AS1 expression and phosphorylated STAT3 in HCC tissues. (A) The transcriptional ex...

Additional file 7: of Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling

Min-Hui Yang (503238)
Li Zhao (147498)
Lan Wang (85307)
Wen Ou-Yang (6417875)
Sha-Sha Hu (6417878)
Wen-Lu Li (6417881)
Mei-Ling Ai (6417884)
Yi-Qing Wang (5515640)
Yue Han (560788)
Ting-Ting Li (32847)
Yan-Qing Ding (458014)
Shuang Wang (46453)

March 2019

Figure S5. HOXD3 is required for the HOXD-AS1-mediated progress of CRC in vitro. (a) Real-time PCR a...

Additional file 6: of Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin Î˛3 transcriptional activating and MAPK/AKT signalling

Min-Hui Yang (503238)
Li Zhao (147498)
Lan Wang (85307)
Wen Ou-Yang (6417875)
Sha-Sha Hu (6417878)
Wen-Lu Li (6417881)
Mei-Ling Ai (6417884)
Yi-Qing Wang (5515640)
Yue Han (560788)
Ting-Ting Li (32847)
Yan-Qing Ding (458014)
Shuang Wang (46453)

March 2019

Figure S4. HOXD-AS1 regulates HOXD3 expression through cooperating with PRC2 complex. (a) RIP assays...

Additional file 2: Figure S1. of Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

Xuening Ji (3540773)
Shi Jin (641785)
Xiaotong Qu (3427790)
Kejun Li (171059)
Hongjiang Wang (171043)
Hui He (356808)
Fuchao Guo (3540770)
Lei Dong (165252)

October 2015

A and B, qChIP was performed to assess H3K27me3 occupancy in HCC L02-pBabe-KDM5C and its control cel...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S1. Prognostic value of CD73 in subgroups of HCC patients. (A) Kaplan–Meier analysis of TTR o...

Additional file 3: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Abstract

Extracted data

Additional file 3: of Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

Abstract

Extracted data

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