Reactivity of anti-PGT121 antibodies in sera from protected macaques against several HIV bnAbs measured by ELISA.
- Yvonne J. Rosenberg (3214905)
- George K. Lewis (376201)
- David C. Montefiori (108747)
- Celia C. LaBranche (172138)
- Mark G. Lewis (67670)
- Lori A. Urban (6383921)
- Jonathan P. Lees (3214902)
- Lingjun Mao (393670)
- Xiaoming Jiang (393673)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Macaques #12N010 (left) and #JFL (right) were injected twice SC with 5mg/kg PGT121 eight weeks apart and challenged with SHIV SF162P3 24 hr after the first PGT121 injection and one hr before the second PGT121 injection. Sera collected for 2–3 weeks following each challenge was tested for binding against PGT121 (produced in both plants and CHO), 10–1074 (CHO), VRC01 (CHO) and 3BNC117 (plant).</p
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