The increasing emergence of multidrug-resistant microorganisms represents one of the greatest challenges in the clinical management of infectious diseases, and requires the development of novel antimicrobial agents. To this aim, we de novo designed a library of Arg-rich ultra-short cationic antimicrobial lipopeptides (USCLs), based on the Arg-X-Trp-Arg-NH2 peptide moiety conjugated with a fatty acid, and investigated their antibacterial potential. USCLs exhibited an excellent antimicrobial activity against clinically pathogenic microorganisms, in particular Gram-positive bacteria, including multidrug resistant strains, with MIC values ranging between 1.56 and 6.25 μg/mL. The capability of the two most active molecules, Lau-RIWR-NH2 and Lau-...
AbstractThe prevalence of antibiotic-resistant pathogens is a major medical concern, prompting incre...
As more and more bacteria become resistance against the drugs currently used in the clinic we are in...
AbstractBP100 is a short cationic antimicrobial peptide with a mechanism of action dependent on pept...
8noThe increasing emergence of multidrug-resistant microorganisms represents one of the greatest cha...
The increasing emergence of multidrug-resistant microorganisms represents one of the greatest challe...
The spread of drug-resistant bacteria has imparted a sense of urgency in the search for new antibiot...
Bacterial resistance towards antibiotics is a major global health issue. Very few novel antimicrobia...
There is increasing demand to develop antimicrobial peptides (AMPs) as next generation antibiotic ag...
Free to read at publisher's site. BP100 is a short cationic antimicrobial peptide with a mechanism o...
Background: Much attention has been focused on the design and synthesis of potent, cationic antimicr...
In this research, we constructed a novel engineered tripeptide modified with lipoic acid (LA-RWR), f...
Cationic antimicrobial peptides (CAMPs) are a promising alternative to treat multidrug-resistant bac...
Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new altern...
Creative strategies for identifying new antibiotics are essential to addressing the looming threat o...
Increasing prevalence of bacteria that carries resistance towards conventional antibiotics has promp...
AbstractThe prevalence of antibiotic-resistant pathogens is a major medical concern, prompting incre...
As more and more bacteria become resistance against the drugs currently used in the clinic we are in...
AbstractBP100 is a short cationic antimicrobial peptide with a mechanism of action dependent on pept...
8noThe increasing emergence of multidrug-resistant microorganisms represents one of the greatest cha...
The increasing emergence of multidrug-resistant microorganisms represents one of the greatest challe...
The spread of drug-resistant bacteria has imparted a sense of urgency in the search for new antibiot...
Bacterial resistance towards antibiotics is a major global health issue. Very few novel antimicrobia...
There is increasing demand to develop antimicrobial peptides (AMPs) as next generation antibiotic ag...
Free to read at publisher's site. BP100 is a short cationic antimicrobial peptide with a mechanism o...
Background: Much attention has been focused on the design and synthesis of potent, cationic antimicr...
In this research, we constructed a novel engineered tripeptide modified with lipoic acid (LA-RWR), f...
Cationic antimicrobial peptides (CAMPs) are a promising alternative to treat multidrug-resistant bac...
Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new altern...
Creative strategies for identifying new antibiotics are essential to addressing the looming threat o...
Increasing prevalence of bacteria that carries resistance towards conventional antibiotics has promp...
AbstractThe prevalence of antibiotic-resistant pathogens is a major medical concern, prompting incre...
As more and more bacteria become resistance against the drugs currently used in the clinic we are in...
AbstractBP100 is a short cationic antimicrobial peptide with a mechanism of action dependent on pept...