A non-linear mixed effect model for innate immune response: <i>In vivo</i> kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6 - Fig 6

Final model predictions of the time-courses of endotoxin (A), tumor necrosis factor alpha (B), interleukin-6 (C), and the potency parameter EC50 (D). Different initial infusion rates of endotoxin, in EU/kg/h, were used: Control (designated with a light blue line), 63 (blue), 250 (light green), 500 (green), 1000 (pink), 4000 (red), 8000 (yellow), and 16000 (orange), changed to 4000 EU/kg/h after 15 h for the lower rates of 63, 250, 500, and 1000 EU/kg/h, to demonstrate tolerance aspects. The dashed part of the lines indicate extrapolation beyond the period of the observed data.