Pam2-ODN protects against bacterial pneumonia.
- Hayden H. Ware (6392438)
- Vikram V. Kulkarni (6392441)
- Yongxing Wang (653858)
- Jezreel Pantaleón García (6392444)
- Miguel Leiva Juarez (6392447)
- Carson T. Kirkpatrick (6392450)
- Shradha Wali (673206)
- Sarah Syed (6392453)
- Alexander D. Kontoyiannis (6392456)
- William K. A. Sikkema (574881)
- James M. Tour (1274196)
- Scott E. Evans (334075)
Publication date
February 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Survival of wildtype mice treated with Pam2-ODN or PBS (sham) by aerosol 24 h before challenge with P. aeruginosa. (B) Pathogen burden of mice in A immediately after challenge, as assessed by serial dilution culture of lung homogenates (left panel) or BAL fluid (right panel). (C) Gross appearance of mouse lungs 24 h after P. aeruginosa challenge following treatment with Pam2-ODN or sham. (D) Hematoxylin-eosin stained histology of lungs in C. Scale bar = 400 μm left panels, 100 μm right panels. Each panels is representative of at least three independent experiments. N = 8 mice/group for survival, N = 4 mice/group for pathogen burden. * p < 0.0002 vs. PBS-treated; ** p < 0.002 vs PBS-treated.</p
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