ROBO4 integrates several functional networks including a neo-functionalized network regulating angiogenesis.

ROBO4 is an endothelial-specific network hub, and a signaling bridge which integrates three functional sub-networks of the vertebrate cell: (1) the angiogenesis network, (2) the actin/filopodia network, and (3) the axon guidance network. The legend beneath the network graph provides information on sources of evidence and scores obtained for the interactors. Functional enrichment analysis at the bottom of the figure provides information on enriched gene ontology terms and KEGG pathways. Roman numbers indicate two sets of ohnologs: ROBO1 and ROBO4 (I) and SLIT1-3 (II).