Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T‑cell Acute Lymphoblastic Leukemia
- Deborah Quaglio (1716880)
- Nadezda Zhdanovskaya (6420557)
- Gloria Tobajas (6420560)
- Viviana Cuartas (6420563)
- Silvia Balducci (6420566)
- Michael S. Christodoulou (4335637)
- Giancarlo Fabrizi (1565929)
- Marta Gargantilla (6420569)
- Eva-María Priego (1801138)
- Álvaro Carmona Pestaña (6420572)
- Daniele Passarella (129791)
- Isabella Screpanti (120411)
- Bruno Botta (470312)
- Rocco Palermo (8836)
- Mattia Mori (103397)
- Francesca Ghirga (1716886)
- María-Jesús Pérez-Pérez (1801144)
Publication date
March 2019
DOI Publisher
American Chemical Society (ACS)Abstract
Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent
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