Additional file 6 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Additional file 5: of Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Gaurav Chatterjee (5998253)
Trupti Pai (5998256)
Thomas Hardiman (5876474)
Kelly Avery-Kiejda (3534812)
Rodney Scott (279337)
Jo Spencer (267903)
Sarah Pinder (553692)
Anita Grigoriadis (41195)

November 2018

Table S5. Differentially expressed genes representing specific immune cell populations across all th...

Additional file 5 of Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs

Tenghui Han (11282788)
Dong Xu (21616)
Jun Zhu (84054)
Jipeng Li (533978)
Lei Liu (5074)
Yanchun Deng (11282791)

August 2021

Additional file 5: Figure S2. TICs with differential profiles between cluster1 and cluster2. (a) Mac...

Additional file 1: of Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Xu Zhang (49484)
Hui Shi (278337)
Xiao Yuan (522103)
Pengcheng Jiang (2015869)
Hui Qian (110856)
Wenrong Xu (110863)

October 2018

Figure S1. Gastric cancer cell-derived conditioned medium induced pro-inflammatory factor gene expre...

Additional file 5 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Table S4. Correlations between mast cell percentage and clinic pathological features of patients wit...

Additional file 4 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Table S2. Clinical characteristics of 114 patients with gastric cancer. (DOCX 19 kb

Additional file 12 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S7. Kaplan-Meier plots for disease-free survival by median mast cell percentage (9.315%) or m...

Additional file 2 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S1. Mast cell percentage (a) or mast cell number (b) and its potential correlations with clin...

Additional file 8 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S3. Tumor-derived factor TNF-α induces mast cells to express PD-L1. (a) Expression of 2B4, gl...

Additional file 9 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S4. Tumor-derived TNF-α activates NF-κB pathway to induce PD-L1 expression on mast cells. (a)...

Additional file 7 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S2. CXCL12-CXCR4 chemotaxis mediates mast cell migration and accumulation in GC tumors. (a) E...

Additional file 10 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S5. Tumor-infiltrating and tumor-conditioned mast cells suppress T cell immunity through PD-L...

Additional file 11 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S6. Blockade of mast cell-associated PD-L1 on T cell immunity inhibits tumor growth and GC pr...

Additional file 1: of Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

Xiaobo Bo (4991792)
Jie Wang (16762)
Tao Suo (325889)
Xiaoling Ni (3927122)
Han Liu (288039)
Sheng Shen (584608)
Min Li (12799)
Yueqi Wang (4962742)
Houbao Liu (4991795)
Jiejie Xu (389064)

March 2018

Table S1. Association between CD8+ T cells infiltration and patient characteristics. (DOC 64 kb

Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv
Yongliang Zhao
Xianhua Wang
Na Chen
Fangyuan Mao
Yongsheng Teng
Tingting Wang
Liusheng Peng
Jinyu Zhang
Ping Cheng
Yugang Liu
Hui Kong
Weisan Chen
Chuanjie Hao
Bin Han
Qiang Ma
Quanming Zou
Jun Chen
Yuan Zhuang

February 2019

Abstract Background Mast cells are prominent components of solid tumors and exhibit distinct phenoty...

Additional file 5: of Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer

In-Hye Ham (574983)
Hye Jeong Oh (6530528)
Hyejin Jin (3706306)
Cheong A Bae (6530531)
Sang-Min Jeon (2794516)
Kyeong Sook Choi (511765)
Sang-Yong Son (6530534)
Sang-Uk Han (574986)
Rolf Brekken (258436)
Dakeun Lee (3706303)
Hoon Hur (574980)

March 2019

Table S1. The genes with highest co-expression correlation with IL-6 in TCGA gastric cancer dataset....

Additional file 5: of Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Gaurav Chatterjee (5998253)
Trupti Pai (5998256)
Thomas Hardiman (5876474)
Kelly Avery-Kiejda (3534812)
Rodney Scott (279337)
Jo Spencer (267903)
Sarah Pinder (553692)
Anita Grigoriadis (41195)

November 2018

Table S5. Differentially expressed genes representing specific immune cell populations across all th...

Additional file 5 of Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs

Tenghui Han (11282788)
Dong Xu (21616)
Jun Zhu (84054)
Jipeng Li (533978)
Lei Liu (5074)
Yanchun Deng (11282791)

August 2021

Additional file 5: Figure S2. TICs with differential profiles between cluster1 and cluster2. (a) Mac...

Additional file 1: of Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Xu Zhang (49484)
Hui Shi (278337)
Xiao Yuan (522103)
Pengcheng Jiang (2015869)
Hui Qian (110856)
Wenrong Xu (110863)

October 2018

Figure S1. Gastric cancer cell-derived conditioned medium induced pro-inflammatory factor gene expre...

Additional file 5 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Table S4. Correlations between mast cell percentage and clinic pathological features of patients wit...

Additional file 4 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Table S2. Clinical characteristics of 114 patients with gastric cancer. (DOCX 19 kb

Additional file 12 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S7. Kaplan-Meier plots for disease-free survival by median mast cell percentage (9.315%) or m...

Additional file 2 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S1. Mast cell percentage (a) or mast cell number (b) and its potential correlations with clin...

Additional file 8 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S3. Tumor-derived factor TNF-α induces mast cells to express PD-L1. (a) Expression of 2B4, gl...

Additional file 9 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S4. Tumor-derived TNF-α activates NF-κB pathway to induce PD-L1 expression on mast cells. (a)...

Additional file 7 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S2. CXCL12-CXCR4 chemotaxis mediates mast cell migration and accumulation in GC tumors. (a) E...

Additional file 10 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S5. Tumor-infiltrating and tumor-conditioned mast cells suppress T cell immunity through PD-L...

Additional file 11 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv (5847563)
Yongliang Zhao (400757)
Xianhua Wang (423878)
Na Chen (153323)
Fangyuan Mao (746320)
Yongsheng Teng (6405083)
Tingting Wang (123983)
Liusheng Peng (6405086)
Jinyu Zhang (310913)
Ping Cheng (289811)
Yugang Liu (602354)
Hui Kong (4516105)
Weisan Chen (5881)
Chuanjie Hao (6405089)
Bin Han (45760)
Qiang Ma (441889)
Quanming Zou (147799)
Jun Chen (4238)
Yuan Zhuang (478696)

February 2019

Figure S6. Blockade of mast cell-associated PD-L1 on T cell immunity inhibits tumor growth and GC pr...

Additional file 1: of Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

Xiaobo Bo (4991792)
Jie Wang (16762)
Tao Suo (325889)
Xiaoling Ni (3927122)
Han Liu (288039)
Sheng Shen (584608)
Min Li (12799)
Yueqi Wang (4962742)
Houbao Liu (4991795)
Jiejie Xu (389064)

March 2018

Table S1. Association between CD8+ T cells infiltration and patient characteristics. (DOC 64 kb

Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Yipin Lv
Yongliang Zhao
Xianhua Wang
Na Chen
Fangyuan Mao
Yongsheng Teng
Tingting Wang
Liusheng Peng
Jinyu Zhang
Ping Cheng
Yugang Liu
Hui Kong
Weisan Chen
Chuanjie Hao
Bin Han
Qiang Ma
Quanming Zou
Jun Chen
Yuan Zhuang

February 2019

Abstract Background Mast cells are prominent components of solid tumors and exhibit distinct phenoty...

Additional file 5: of Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer

In-Hye Ham (574983)
Hye Jeong Oh (6530528)
Hyejin Jin (3706306)
Cheong A Bae (6530531)
Sang-Min Jeon (2794516)
Kyeong Sook Choi (511765)
Sang-Yong Son (6530534)
Sang-Uk Han (574986)
Rolf Brekken (258436)
Dakeun Lee (3706303)
Hoon Hur (574980)

March 2019

Table S1. The genes with highest co-expression correlation with IL-6 in TCGA gastric cancer dataset....

Additional file 5: of Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients

Gaurav Chatterjee (5998253)
Trupti Pai (5998256)
Thomas Hardiman (5876474)
Kelly Avery-Kiejda (3534812)
Rodney Scott (279337)
Jo Spencer (267903)
Sarah Pinder (553692)
Anita Grigoriadis (41195)

November 2018

Table S5. Differentially expressed genes representing specific immune cell populations across all th...

Additional file 5 of Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs

Tenghui Han (11282788)
Dong Xu (21616)
Jun Zhu (84054)
Jipeng Li (533978)
Lei Liu (5074)
Yanchun Deng (11282791)

August 2021

Additional file 5: Figure S2. TICs with differential profiles between cluster1 and cluster2. (a) Mac...

Additional file 1: of Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Xu Zhang (49484)
Hui Shi (278337)
Xiao Yuan (522103)
Pengcheng Jiang (2015869)
Hui Qian (110856)
Wenrong Xu (110863)

October 2018

Figure S1. Gastric cancer cell-derived conditioned medium induced pro-inflammatory factor gene expre...

Additional file 6 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Abstract

Extracted data

Additional file 6 of Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-Îą-PD-L1 pathway

Abstract

Extracted data

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