(A, B) Cardiomyocyte proliferation (Ki67) and mitosis (phospho-Histone 3Ser10 positive immunostaining) in postnatal day 1 TeadF/F and Tead1-cKO hearts. (C, D) Quantitative analysis represents counting of multiple sections from three independent samples per group (approximately 1.2–1.5 X 105 cardiomyocytes were counted). **p t-test. Scale bar, 20 μm.</p
<p>(A) Heart weight (HW) normalized to body weight (BW) in tTA and NLK DTG mice at the indicated age...
<p>(A) TUNEL (terminal deoxynucleotidyltransferase-mediated UTP end labeling) assays were performed ...
<p>(A-B) PhosphoHistoneH3/Nkx2-5/YFP immunofluorescence of left ventricular cardiomyocytes from E14....
Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte...
Data are presented as mean ± s.e.m. ***p p p t-test. Comparisons between (A) Tead1-cKO pups and Tead...
(A) Generation of Tead1 cardiomyocyte-specific knockout mice (Tead1-cKO) using knockout-first strate...
(A) Heart weight (B) Body weight and (C) heart weight to body weight ratios of Tead1-cKO mice at pos...
Echocardiography on postnatal day 1 neonatal pups. (A) Representative image of the echocardiography....
<p>Immunofluorescent staining showing the presence of proliferating Ki-67<sup>+</sup> (A) and mitoti...
Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, ...
<p>Flow cytometry analysis showed that the percentage of Ki67-positive cardiomyocytes was similar in...
SummaryIt is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesi...
Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, ...
<p>Confocal microscopy of tissue sections using Ki67 and troponin indicate that non-cardiomyocyte ce...
<p>Cardiomyocytes were isolated from 2 day-old neonatal hearts and cultured on gelatin-coated dishes...
<p>(A) Heart weight (HW) normalized to body weight (BW) in tTA and NLK DTG mice at the indicated age...
<p>(A) TUNEL (terminal deoxynucleotidyltransferase-mediated UTP end labeling) assays were performed ...
<p>(A-B) PhosphoHistoneH3/Nkx2-5/YFP immunofluorescence of left ventricular cardiomyocytes from E14....
Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte...
Data are presented as mean ± s.e.m. ***p p p t-test. Comparisons between (A) Tead1-cKO pups and Tead...
(A) Generation of Tead1 cardiomyocyte-specific knockout mice (Tead1-cKO) using knockout-first strate...
(A) Heart weight (B) Body weight and (C) heart weight to body weight ratios of Tead1-cKO mice at pos...
Echocardiography on postnatal day 1 neonatal pups. (A) Representative image of the echocardiography....
<p>Immunofluorescent staining showing the presence of proliferating Ki-67<sup>+</sup> (A) and mitoti...
Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, ...
<p>Flow cytometry analysis showed that the percentage of Ki67-positive cardiomyocytes was similar in...
SummaryIt is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesi...
Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, ...
<p>Confocal microscopy of tissue sections using Ki67 and troponin indicate that non-cardiomyocyte ce...
<p>Cardiomyocytes were isolated from 2 day-old neonatal hearts and cultured on gelatin-coated dishes...
<p>(A) Heart weight (HW) normalized to body weight (BW) in tTA and NLK DTG mice at the indicated age...
<p>(A) TUNEL (terminal deoxynucleotidyltransferase-mediated UTP end labeling) assays were performed ...
<p>(A-B) PhosphoHistoneH3/Nkx2-5/YFP immunofluorescence of left ventricular cardiomyocytes from E14....