Core from HCV infected patients variably stimulate NLRP3 inflammasome activation.

(A) IL-1β ELISA. HCV core, from acutely infected individuals, expressing constructs co-transfected with NLRP3 inflammasome components. (B) western blot depicting the expression of the patient-derived core as well as the inflammasome components. Experiments were performed with three replicates and are representative of four independent experiments. Data are represented as means and +/- SD, *P<0.05, **P<0.01, ***P<0.001 and ns = non-significant.