Py17XNL-immune and non-immune mice (n = 5/group) were transferred with CTFR+Py17XNL-infected pRBC, with peripheral RBC monitored at timepoints indicated for: (A) loss of Gen0 (CTFR+) pRBC over the first 25 hours, and (B) emergence over 3 days of Gen1+ (CTFR-) pRBC, with zoomed-in box showing the first 25 hours in more detail. All data representative of two independent experiments showing similar results.</p
<p>BALB/c and <i>Cr2<sup>−/−</sup></i> mice were irradiated and reconstituted with either BALB/c or ...
(A) Representative western blot showing shed PrP (detected with our new antibody described in [36]) ...
<p>(A) PrP immuno-depletion selectively depleted ~77 ± 12% of PrP<sup>C</sup> (dNBH) from cNBH and ~...
(A) Schematic showing that mice (n = 5/group) were injected with serum from Py17XNL-immune or non-im...
(A) Schematic showing that mice (n = 5/group) were injected with immune or non-immune control serum ...
(A) Schematic showing that 4 groups of mice (n = 5/group) were treated with clodronate liposomes or ...
Detection of in vitro deposited IgG from immune or non-immune control serum either (A) on the surfac...
(A) Assessment of PcAS-specific total IgG in diluted sera from infected or age-matched naïve mice (n...
<p>Brain and spleen samples from C57Bl/10 mice inoculated with rPrP-res, 22L mouse scrapie, vehicle ...
Phenotypic studies of mice with altered levels of PrPc expression showed differences in lymphocyte s...
<p>Mice were inoculated with classical CJD and GSS A117V brain. Immunoblots were analysed by enhance...
Prion diseases are associated with the conversion of the normal host cellular prion protein to an ab...
The involvement of immune cells in prion capture and transport to lymphoid tissues still remains unc...
<p>Spleen of Prp<sup>0/0</sup> mice lethally irradiated reconstituted with femoral bone marrow cells...
<p>(<b>A–B</b>) C57Bl/6 mice were infected with 1×10<sup>6</sup> IFU CP i. t. and were injected i. p...
<p>BALB/c and <i>Cr2<sup>−/−</sup></i> mice were irradiated and reconstituted with either BALB/c or ...
(A) Representative western blot showing shed PrP (detected with our new antibody described in [36]) ...
<p>(A) PrP immuno-depletion selectively depleted ~77 ± 12% of PrP<sup>C</sup> (dNBH) from cNBH and ~...
(A) Schematic showing that mice (n = 5/group) were injected with serum from Py17XNL-immune or non-im...
(A) Schematic showing that mice (n = 5/group) were injected with immune or non-immune control serum ...
(A) Schematic showing that 4 groups of mice (n = 5/group) were treated with clodronate liposomes or ...
Detection of in vitro deposited IgG from immune or non-immune control serum either (A) on the surfac...
(A) Assessment of PcAS-specific total IgG in diluted sera from infected or age-matched naïve mice (n...
<p>Brain and spleen samples from C57Bl/10 mice inoculated with rPrP-res, 22L mouse scrapie, vehicle ...
Phenotypic studies of mice with altered levels of PrPc expression showed differences in lymphocyte s...
<p>Mice were inoculated with classical CJD and GSS A117V brain. Immunoblots were analysed by enhance...
Prion diseases are associated with the conversion of the normal host cellular prion protein to an ab...
The involvement of immune cells in prion capture and transport to lymphoid tissues still remains unc...
<p>Spleen of Prp<sup>0/0</sup> mice lethally irradiated reconstituted with femoral bone marrow cells...
<p>(<b>A–B</b>) C57Bl/6 mice were infected with 1×10<sup>6</sup> IFU CP i. t. and were injected i. p...
<p>BALB/c and <i>Cr2<sup>−/−</sup></i> mice were irradiated and reconstituted with either BALB/c or ...
(A) Representative western blot showing shed PrP (detected with our new antibody described in [36]) ...
<p>(A) PrP immuno-depletion selectively depleted ~77 ± 12% of PrP<sup>C</sup> (dNBH) from cNBH and ~...