dKO male mice display increased p38 activity.

Cardiac hypertrophy was induced by TAC in male mice. Eight weeks following TAC, mice were sacrificed and hearts were excised A Western blot analysis of heart lysate derived from the indicated genotypes with the indicated antibodies. B-C Densitometric analysis of Western blot shown in A is presented as mean ratio of the corresponding phospho-protein to total protein ± SE (compared to wild type control, defined as 1, n = 5-6/group). B pp38/p38. C pERK/ERK. ***P ≤ 0.05, control vs. TAC; †P ≤ 0.05 difference between genotypes.