Breakdown of exposure-response genes by exposure duration and response to smoke.

The Sankey diagram breaks down the genes in a hierarchical manner, and the area of the shape is proportional to the number of genes represented. Purple indicates results from 1 day of exposure; green indicates results from 5 days of exposure. (A): Sankey diagram showing the proportion of exposure-response genes additionally affected by genotype and/or sex: 56% of the exposure-response genes at 1 day and 41% of the genes at 5 days are further modulated by genotype and/or sex. At 1 day, 70 of the exposure-response genes were also influenced by genotype and 93 genes were also influenced by sex, while 21 of the exposure-response genes were influenced independently by exposure, genotype, and sex. After 5 days, 130 of the exposure-response genes were also influenced by genotype and 7 genes were also influenced by sex. Four genes were influenced independently by exposure, genotype, and sex. (B): Sankey diagram showing the proportion of exposure-response genes that are unique to each exposure duration (green and purple) compared to the proportion that responds significantly after both 1 and 5 days (orange). 556 total exposure-response genes were identified at 1 and/or 5 days of smoke exposure. At 1 day, 330 exposure-genes were identified. 209 of these genes were uniquely significantly associated with the 1 day exposure, while 121 genes were also identified as significantly associated after 5 days. After 5 days, 347 exposure-genes were identified, 226 of which were uniquely significantly associated with 5 days of exposure. Diagrams created using SankeyMATIC.