Dal80 spreading across the coding region of a subset of genes.

(A) Identification of genes showing Dal80 intragenic binding. Dal80-bound ORFs were identified on the basis of a >75% overlap of the ORF by a Dal80-Myc13 peak (represented as a red dashed line). (B) Venn diagram showing the number of genes that are bound by Dal80 at the promoter and across the coding region (ORF). (C) Metagene view of the ChIP-Seq signal along the ATG +/- 600 bp region for the 1125 genes identified as bound by Dal80 at the promoter only (“P” class), in untagged (black) and DAL80-MYC13 cells (blue). MetaSignal computation was as described in Fig 1D. The shading surrounding each line denotes the 95% confidence interval. (D) Same as above for the 144 genes bound by Dal80 at the promoter and across the ORF (“P&O” class). (E) Same as above for the 45 genes bound by Dal80 across the ORF only (“O” class). (F) Same as above for the 4484 genes that are not bound by Dal80.