Altered response to LPS in QKO mice.

Male QKO and control mice were treated with LPS (250 μg/kg, i.p.) or vehicle. Adjusted P values (from two-way ANOVA with Tukey multiple comparisons test; N = 11–12/group) are for effect of vehicle versus LPS within genotype (S6 Table). The numerical data are in Supporting information. i.p., intraperitoneal; LPS, lipopolysaccharide; QKO, quad knockout; Tb, core body temperature; WT, wild-type.