Interleukin-6 (IL-6) is a pleotropic cytokine that signals through the membrane-bound IL-6 receptor (mIL-6R) to induce antiinflammatory(‘‘classic-signaling’’) responses. This cytokine also binds to the soluble IL-6R (sIL-6R) to promote inflammation(‘‘trans-signaling’’). mIL-6R expression is restricted to hepatocytes and immune cells. Activated T cells release sIL-6R into adjacenttissues to induce trans-signaling. These cellular actions require the ubiquitously expressed membrane receptor gp130. Reportsshow that IL-6 is produced by pulmonary arterial smooth muscle cells (PASMCs) exposed to hypoxia in culture as well as themedial layer of the pulmonary arteries in mice exposed to chronic hypoxia (CH), and IL-6 knockout mice are protected from...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Reactive oxygen species, particularly superoxide, promote endothelial dysfunction and alterations in...
Abstract Background Inflammation may contribute to the pathogenesis of various forms of pulmonary hy...
Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with pulmona...
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or th...
Inflammation is a prominent pathologic feature in pulmonary arterial hypertension as demonstrated by...
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or th...
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or th...
AbstractAimsSevere pulmonary arterial hypertension (PAH) is an incurable disease whose exact mechani...
Metabolic reprogramming-driven inflammation is emerging as central processes in the pathogenesis of ...
The multifunctional cytokine interleukin (IL)-6 has been shown to modulate inflammation and angiogen...
Myeloid cells, such as neutrophils, are produced in the bone marrow in high quantities and are impor...
Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death wit...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Reactive oxygen species, particularly superoxide, promote endothelial dysfunction and alterations in...
Abstract Background Inflammation may contribute to the pathogenesis of various forms of pulmonary hy...
Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with pulmona...
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or th...
Inflammation is a prominent pathologic feature in pulmonary arterial hypertension as demonstrated by...
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or th...
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or th...
AbstractAimsSevere pulmonary arterial hypertension (PAH) is an incurable disease whose exact mechani...
Metabolic reprogramming-driven inflammation is emerging as central processes in the pathogenesis of ...
The multifunctional cytokine interleukin (IL)-6 has been shown to modulate inflammation and angiogen...
Myeloid cells, such as neutrophils, are produced in the bone marrow in high quantities and are impor...
Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death wit...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are...
Reactive oxygen species, particularly superoxide, promote endothelial dysfunction and alterations in...