RNA binding motif 20 (RBM20) regulates pre-mRNA splicing of over thirty genes, among which titin is a major target. With RBM20 expression, titin expresses a larger isoform at fetal stage to a smaller isoform at adult resulting from alternative splicing, while, without RBM20, titin expresses exclusively a larger isoform throughout all ages. In addition to splicing regulation, it is unknown whether RBM20 also regulates gene expression. In this study, we employed Rbm20 knockout rats to investigate gene expression profile using Affymetrix expression array. We compared wild type to Rbm20 knockout at day1, 20 and 49. Bioinformatics analysis showed RBM20 regulates fewer genes expression at younger age and more at older age and commonly expresse...
Splice regulators play an essential role in the transcriptomic diversity of all eukaryotic cell type...
Recent studies showed that RNA binding motif protein 20 (RBM20) is involved in the regulation of the...
RBM20 is a major regulator of heart-specific alternative pre-mRNA splicing of TTN encoding a giant s...
<p><br></p> <p> RNA binding motif 20 (RBM20) regulates pre-mRNA splicing of over thirty genes, among...
<div><p>Our recent study indicated that RNA binding motif 20 (Rbm20) alters splicing of titin and ot...
Titin, a sarcomeric protein expressed primarily in striated muscles, is responsible for maintaining ...
RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recog...
Mutations in the RS-domain of RNA-binding motif protein 20 (RBM20) have recently been identified to ...
Contains fulltext : 139221.pdf (publisher's version ) (Open Access)Mutations in th...
Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in dilated cardiom...
RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recog...
<p>Titin, a giant sarcomeric protein, is largely responsible for the diastolic properties of the hea...
Alternative splicing is an essential post-transcriptional process to generate multiple functional...
Cardiomyopathy, also known as heart muscle dis- ease, is an unfavorable condition leading to alt...
Recent studies showed that RNA binding motif protein 20 (RBM20) is involved in the regulation of th...
Splice regulators play an essential role in the transcriptomic diversity of all eukaryotic cell type...
Recent studies showed that RNA binding motif protein 20 (RBM20) is involved in the regulation of the...
RBM20 is a major regulator of heart-specific alternative pre-mRNA splicing of TTN encoding a giant s...
<p><br></p> <p> RNA binding motif 20 (RBM20) regulates pre-mRNA splicing of over thirty genes, among...
<div><p>Our recent study indicated that RNA binding motif 20 (Rbm20) alters splicing of titin and ot...
Titin, a sarcomeric protein expressed primarily in striated muscles, is responsible for maintaining ...
RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recog...
Mutations in the RS-domain of RNA-binding motif protein 20 (RBM20) have recently been identified to ...
Contains fulltext : 139221.pdf (publisher's version ) (Open Access)Mutations in th...
Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in dilated cardiom...
RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recog...
<p>Titin, a giant sarcomeric protein, is largely responsible for the diastolic properties of the hea...
Alternative splicing is an essential post-transcriptional process to generate multiple functional...
Cardiomyopathy, also known as heart muscle dis- ease, is an unfavorable condition leading to alt...
Recent studies showed that RNA binding motif protein 20 (RBM20) is involved in the regulation of th...
Splice regulators play an essential role in the transcriptomic diversity of all eukaryotic cell type...
Recent studies showed that RNA binding motif protein 20 (RBM20) is involved in the regulation of the...
RBM20 is a major regulator of heart-specific alternative pre-mRNA splicing of TTN encoding a giant s...