Responses of two-compartment models to 500 Hz coincident inputs.

A: Schematic diagrams indicating coupling configurations for the weakly-coupled (left column), forward-coupled (middle column), and strongly-coupled (right column) models. B: Responses of passive models (gNa = 0 nS). Darker colors indicate V1 (responses in Cpt1) and lighter colors indicate V2 (responses in Cpt2). V1 dynamics are nearly identical for all coupling configuration, as expected from our parameterization method. C: Responses of two-compartment models with . Occurrence and shape of spikes depends on coupling configuration, even though inputs are identical in all simulations. Notice the difference in y-axes; amplitude of V2 spikes is largest in the weakly-coupled model.