Stem cell therapy is one of the most promising strategies to restore blood perfusion and promote muscleregeneration in ischemic limbs. Yet its therapeutic efficacy remains low owing to the inferior cell survivalunder the low oxygen and nutrient environment of the injured limbs. To increase therapeutic efficacy,high rates of both short- and long-term cell survival are essential, which current approaches do not support.In this work, we hypothesized that a high rate of short-term cell survival can be achieved by introducinga prosurvival environment into the stem cell delivery system to enhance cell survival beforevascularization is established; and that a high rate of long-term cell survival can be attained by buildinga proangiogenic environme...
Background—Aging and aging-related disorders impair the survival and differentiation potential of bo...
Coronary (CAD) and peripheral (PAD) artery diseases are major causes of morbidity and mortality, and...
Objective—To test the therapeutic activity of perivascular transplantation of encapsulated human mes...
Mesenchymal stem/stromal cells (MSCs) offer great promise in the treatment of ischemic injuries, inc...
International audienceBackground: Cell therapy has been proposed for patients with critical limb isc...
ObjectiveAngiogenesis involves the interplay of endothelial progenitor cells, pericytes, growth fact...
Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and...
Ischemia is a potentially fatal medical event that is associated with as many as 30% of all deaths. ...
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can activel...
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can activel...
The degree of symptomatology of a patient with peripheral arterial disease dictates the kind of trea...
Background: Due to stimulation of muscular regeneration in ischemic extremities and increasing blood...
Background: Aging and aging-related disorders impair the survival and differentiation potential of b...
Restoring blood flow to ischemic tissue is a prerequisite for treatment of ischemic diseases. Cell-b...
Severe Limb Ischemia (SLI) is the most advanced stage of peripheral arterial disease; patients prese...
Background—Aging and aging-related disorders impair the survival and differentiation potential of bo...
Coronary (CAD) and peripheral (PAD) artery diseases are major causes of morbidity and mortality, and...
Objective—To test the therapeutic activity of perivascular transplantation of encapsulated human mes...
Mesenchymal stem/stromal cells (MSCs) offer great promise in the treatment of ischemic injuries, inc...
International audienceBackground: Cell therapy has been proposed for patients with critical limb isc...
ObjectiveAngiogenesis involves the interplay of endothelial progenitor cells, pericytes, growth fact...
Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and...
Ischemia is a potentially fatal medical event that is associated with as many as 30% of all deaths. ...
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can activel...
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can activel...
The degree of symptomatology of a patient with peripheral arterial disease dictates the kind of trea...
Background: Due to stimulation of muscular regeneration in ischemic extremities and increasing blood...
Background: Aging and aging-related disorders impair the survival and differentiation potential of b...
Restoring blood flow to ischemic tissue is a prerequisite for treatment of ischemic diseases. Cell-b...
Severe Limb Ischemia (SLI) is the most advanced stage of peripheral arterial disease; patients prese...
Background—Aging and aging-related disorders impair the survival and differentiation potential of bo...
Coronary (CAD) and peripheral (PAD) artery diseases are major causes of morbidity and mortality, and...
Objective—To test the therapeutic activity of perivascular transplantation of encapsulated human mes...